Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Jul 11

PMID 26161400

Citations 4

Authors

A Curioni-Fontecedro

R Pitocco

N L Schoenewolf

D Holzmann

D Soldini

R Dummer

S Calvieri

H Moch

D Mihic-Probst

A Fitsche

Affiliations

Soon will be listed here.

Abstract

Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expression throughout the different subtypes of mucosal melanoma and tumor development. We detected a frequent expression of CT7 in primaries and corresponding metastases (55%) as well as for CT10 (30%). This expression resulted to be heterogeneous in the same tumor specimen and moreover influenced by the tissue of origin. Our results support the role of these antigens in immunotherapy for mucosal melanoma.

Citing Articles

The Dual Roles of MAGE-C2 in p53 Ubiquitination and Cell Proliferation Through E3 Ligases MDM2 and TRIM28.

Liu Y, Cao B, Hu L, Ye J, Tian W, He X Front Cell Dev Biol. 2022; 10:922675.

PMID: 35927984 PMC: 9344466. DOI: 10.3389/fcell.2022.922675.

Erratum to "Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma".

Curioni-Fontecedro A, Pitocco R, Schoenewolf N, Holzmann D, Soldini D, Dummer R Biomed Res Int. 2019; 2019:5256364.

PMID: 31428638 PMC: 6679846. DOI: 10.1155/2019/5256364.

Untouchable genes in the human genome: Identifying ideal targets for cancer treatment.

Gorlov I, Gorlova O, Amos C Cancer Genet. 2019; 231-232:67-79.

PMID: 30803560 PMC: 6727980. DOI: 10.1016/j.cancergen.2019.01.005.

Intratumor and Intertumor Heterogeneity in Melanoma.

Grzywa T, Paskal W, Wlodarski P Transl Oncol. 2017; 10(6):956-975.

PMID: 29078205 PMC: 5671412. DOI: 10.1016/j.tranon.2017.09.007.

References

Curioni-Fontecedro A, Nuber N, Mihic-Probst D, Seifert B, Soldini D, Dummer R . Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients. PLoS One. 2011; 6(6):e21418. PMC: 3124507. DOI: 10.1371/journal.pone.0021418. View

Zhuang R, Zhu Y, Fang L, Liu X, Tian Y, Chen L . Generation of monoclonal antibodies to cancer/testis (CT) antigen CT10/MAGE-C2. Cancer Immun. 2006; 6:7. View

Schoenewolf N, Bull C, Belloni B, Holzmann D, Tonolla S, Lang R . Sinonasal, genital and acrolentiginous melanomas show distinct characteristics of KIT expression and mutations. Eur J Cancer. 2012; 48(12):1842-52. DOI: 10.1016/j.ejca.2012.02.049. View

Roth T, Gengler C, Huber G, Holzmann D . Outcome of sinonasal melanoma: clinical experience and review of the literature. Head Neck. 2010; 32(10):1385-92. DOI: 10.1002/hed.21340. View

Tinguely M, Jenni B, Knights A, Lopes B, Korol D, Rousson V . MAGE-C1/CT-7 expression in plasma cell myeloma: sub-cellular localization impacts on clinical outcome. Cancer Sci. 2008; 99(4):720-5. PMC: 11158032. DOI: 10.1111/j.1349-7006.2008.00738.x. View

Godelaine D, Carrasco J, Brasseur F, Neyns B, Thielemans K, Boon T . A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44. Cancer Immunol Immunother. 2006; 56(6):753-9. PMC: 11030963. DOI: 10.1007/s00262-006-0244-5. View

Peng J, Chen H, Mou D, Cao J, Cong X, Qin L . Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters. Cancer Lett. 2005; 219(2):223-32. DOI: 10.1016/j.canlet.2004.07.028. View

Dhodapkar M, Osman K, Teruya-Feldstein J, Filippa D, Hedvat C, Iversen K . Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease. Cancer Immun. 2003; 3:9. View

Barrow C, Browning J, MacGregor D, Davis I, Sturrock S, Jungbluth A . Tumor antigen expression in melanoma varies according to antigen and stage. Clin Cancer Res. 2006; 12(3 Pt 1):764-71. DOI: 10.1158/1078-0432.CCR-05-1544. View

10.

De Smet C, Lurquin C, Lethe B, Martelange V, Boon T . DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol. 1999; 19(11):7327-35. PMC: 84726. DOI: 10.1128/MCB.19.11.7327. View

11.

Yang B, Wu J, Maddodi N, Ma Y, Setaluri V, Longley B . Epigenetic control of MAGE gene expression by the KIT tyrosine kinase. J Invest Dermatol. 2007; 127(9):2123-8. DOI: 10.1038/sj.jid.5700836. View

12.

Luftl M, Schuler G, Jungbluth A . Melanoma or not? Cancer testis antigens may help. Br J Dermatol. 2004; 151(6):1213-8. DOI: 10.1111/j.1365-2133.2004.06260.x. View

13.

Hamid O, Robert C, Daud A, Hodi F, Hwu W, Kefford R . Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013; 369(2):134-44. PMC: 4126516. DOI: 10.1056/NEJMoa1305133. View

14.

Kligora C, Fair K, Clem M, Patterson J . A comparison of melanin bleaching and azure blue counterstaining in the immunohistochemical diagnosis of malignant melanoma. Mod Pathol. 2000; 12(12):1143-7. View

15.

Scanlan M, Simpson A, Old L . The cancer/testis genes: review, standardization, and commentary. Cancer Immun. 2004; 4:1. View

16.

Nuber N, Curioni-Fontecedro A, Matter C, Soldini D, Tiercy J, von Boehmer L . Fine analysis of spontaneous MAGE-C1/CT7-specific immunity in melanoma patients. Proc Natl Acad Sci U S A. 2010; 107(34):15187-92. PMC: 2930530. DOI: 10.1073/pnas.1002155107. View

17.

Bhan S, Negi S, Shao C, Glazer C, Chuang A, Gaykalova D . BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Clin Cancer Res. 2011; 17(13):4267-76. PMC: 3172963. DOI: 10.1158/1078-0432.CCR-11-0653. View

18.

Simpson A, Caballero O, Jungbluth A, Chen Y, Old L . Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer. 2005; 5(8):615-25. DOI: 10.1038/nrc1669. View

19.

Postow M, Hamid O, Carvajal R . Mucosal melanoma: pathogenesis, clinical behavior, and management. Curr Oncol Rep. 2012; 14(5):441-8. DOI: 10.1007/s11912-012-0244-x. View

20.

Stanimirov Rossi O, Vital D, Soyka M, Roth T, Huber G, Holzmann D . Multilocular sinonasal malignant melanoma: a poor prognostic subgroup?. Eur Arch Otorhinolaryngol. 2014; 272(1):123-9. DOI: 10.1007/s00405-014-3098-z. View