Rich Club Network Analysis Shows Distinct Patterns of Disruption in Frontotemporal Dementia and Alzheimer's Disease

Overview

Journal Math Vis

Publisher Springer

Date 2015 Jul 11

PMID 26161050

Citations 6

Authors

Madelaine Daianu

Neda Jahanshad

Julio E Villalon-Reina

Mario F Mendez

George Bartzokis

Elvira E Jimenez

Simantini J Karve

Joseph Barsuglia

Paul M Thompson

Affiliations

Soon will be listed here.

Abstract

Diffusion imaging and brain connectivity analyses can reveal the underlying organizational patterns of the human brain, described as complex networks of densely interlinked regions. Here, we analyzed 1.5-Tesla whole-brain diffusion-weighted images from 64 participants - 15 patients with behavioral variant frontotemporal (bvFTD) dementia, 19 with early-onset Alzheimer's disease (EOAD), and 30 healthy elderly controls. Based on whole-brain tractography, we reconstructed structural brain connectivity networks to map connections between cortical regions. We examined how bvFTD and EOAD disrupt the weighted 'rich club' - a network property where high-degree network nodes are more interconnected than expected by chance. bvFTD disrupts both the nodal and global organization of the network in both low- and high-degree regions of the brain. EOAD targets the global connectivity of the brain, mainly affecting the fiber density of high-degree (highly connected) regions that form the rich club network. These rich club analyses suggest distinct patterns of disruptions among different forms of dementia.

Citing Articles

Altered structural connectome of children with auditory processing disorder: a diffusion MRI study.

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Disrupted Patterns of Rich-Club and Diverse-Club Organizations in Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment.

Xue C, Sun H, Hu G, Qi W, Yue Y, Rao J Front Neurosci. 2020; 14:575652.

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A Novel Connectome-Based Electrophysiological Study of Subjective Cognitive Decline Related to Alzheimer's Disease by Using Resting-State High-Density EEG EGI GES 300.

Lazarou I, Georgiadis K, Nikolopoulos S, Oikonomou V, Tsolaki A, Kompatsiaris I Brain Sci. 2020; 10(6).

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Disrupted rich club network in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease.

Daianu M, Mezher A, Mendez M, Jahanshad N, Jimenez E, Thompson P Hum Brain Mapp. 2015; 37(3):868-83.

PMID: 26678225 PMC: 4883024. DOI: 10.1002/hbm.23069.

Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.

Daianu M, Jahanshad N, Nir T, Jack Jr C, Weiner M, Bernstein M Hum Brain Mapp. 2015; 36(8):3087-103.

PMID: 26037224 PMC: 4504816. DOI: 10.1002/hbm.22830.

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