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Peri-pubertal Exposure to Testicular Hormones Organizes Response to Novel Environments and Social Behaviour in Adult Male Rats

Overview
Journal Horm Behav
Date 2015 Jul 11
PMID 26159287
Citations 13
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Abstract

Previous research has shown that exposure to testicular hormones during the peri-pubertal period of life has long-term, organizational effects on adult sexual behaviour and underlying neural mechanisms in laboratory rodents. However, the organizational effects of peri-pubertal testicular hormones on other aspects of behaviour and brain function are less well understood. Here, we investigated the effects of manipulating peri-pubertal testicular hormone exposure on later behavioural responses to novel environments and on hormone receptors in various brain regions that are involved in response to novelty. Male rodents generally spend less time in the exposed areas of novel environments than females, and this sex difference emerges during the peri-pubertal period. Male Lister-hooded rats (Rattus norvegicus) were castrated either before puberty or after puberty, then tested in three novel environments (elevated plus-maze, light-dark box, open field) and in an object/social novelty task in adulthood. Androgen receptor (AR), oestrogen receptor (ER1) and corticotropin-releasing factor receptor (CRF-R2) mRNA expression were quantified in the hypothalamus, hippocampus and medial amygdala. The results showed that pre-pubertally castrated males spent more time in the exposed areas of the elevated-plus maze and light-dark box than post-pubertally castrated males, and also confirmed that peri-pubertal hormone exposure influences later response to an opposite-sex conspecific. Hormone receptor gene expression levels did not differ between pre-pubertally and post-pubertally castrated males in any of the brain regions examined. This study therefore demonstrates that testicular hormone exposure during the peri-pubertal period masculinizes later response to novel environments, although the neural mechanisms remain to be fully elucidated.

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References
1.
Stewart J, Cygan D . Ovarian hormones act early in development to feminize adult open-field behavior in the rat. Horm Behav. 1980; 14(1):20-32. DOI: 10.1016/0018-506x(80)90012-4. View

2.
Slob A, Bogers H, van Stolk M . Effects of gonadectomy and exogenous gonadal steroids on sex differences in open field behaviour of adult rats. Behav Brain Res. 1981; 2(3):347-62. DOI: 10.1016/0166-4328(81)90017-6. View

3.
Hyde J, Jerussi T . Sexual dimorphism in rats with respect to locomotor activity and circling behavior. Pharmacol Biochem Behav. 1983; 18(5):725-9. DOI: 10.1016/0091-3057(83)90014-x. View

4.
Broida J, Svare B . Sex differences in the activity of mice: modulation by postnatal gonadal hormones. Horm Behav. 1984; 18(1):65-78. DOI: 10.1016/0018-506x(84)90051-5. View

5.
Brand T, Slob A . Peripubertal castration of male rats, adult open field ambulation and partner preference behavior. Behav Brain Res. 1988; 30(2):111-7. DOI: 10.1016/0166-4328(88)90141-6. View