Emergent Transcriptomic Technologies and Their Role in the Discovery of Biomarkers of Liver Transplant Tolerance

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2015 Jul 10

PMID 26157438

Citations 1

Authors

Sotiris Mastoridis

Marc Martinez-Llordella

Alberto Sanchez-Fueyo

Affiliations

Soon will be listed here.

Abstract

Liver transplantation offers a unique window into transplant immunology due, in part, to the considerable proportion of recipients who develop immunological tolerance to their allograft. Biomarkers are able to identify and predict such a state of tolerance, and thereby able to establish suitable candidates for the minimization of hazardous immunosuppressive therapies, are not only of great potential clinical benefit but might also shed light on the immunological mechanisms underlying tolerance and rejection. Here, we review the emergent transcriptomic technologies serving as drivers of biomarker discovery, we appraise efforts to identify a molecular signature of liver allograft tolerance, and we consider the implications of this work on the mechanistic understanding of immunological tolerance.

Citing Articles

Modeling the Potential of Treg-Based Therapies for Transplant Rejection: Effect of Dose, Timing, and Accumulation Site.

Lapp M, Lin G, Komin A, Andrews L, Knudson M, Mossman L Transpl Int. 2022; 35:10297.

PMID: 35479106 PMC: 9035492. DOI: 10.3389/ti.2022.10297.

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