Caspase-1-mediated Cytokine Release from Gestational Tissues, Placental, and Cord Blood

Overview

Journal Front Physiol

Date 2015 Jul 10

PMID 26157394

Citations 8

Authors

Ebtehaj Maneta

Averil Y Warren

Daniel P Hay

Raheela N Khan

Affiliations

Soon will be listed here.

Abstract

Distinguishing between fetal and maternal inflammatory responses is necessary for understanding the immune interplay either side of the placenta. Fetal immunity reaches maturity during extrauterine life and while basic inflammatory responses afford a certain degree of protection, fetuses are vulnerable to infection. With the discovery of inflammasomes-intracellular scaffolds that facilitate the elaboration of reactions resulting in the release of mature interleukin-1β (IL-1β)-it is necessary to consider how inflammatory stimuli are processed. The purinergic P2X7 receptor located on haematopoietic cells is a key intermediary in signal transduction initiated at Toll-like receptors (TLR) terminating in release of the mature IL-1β product. We demonstrate herein that IL-1β release from fetal membranes and mononuclear cells isolated from cord, placental, and maternal blood, obtained at term, is P2X7- and caspase-1 dependent. The P2X7-dependent release of the cytokine, which was highest from choriodecidua, was attenuated by progesterone (P4), prolactin and an NFkB inhibitor. The NLRP3 inflammasome appears necessary for the processing of IL-1β in gestational tissues and leukocytes.

Citing Articles

Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta.

Flores-Espinosa P, Mendez I, Irles C, Olmos-Ortiz A, Helguera-Repetto C, Mancilla-Herrera I Front Immunol. 2023; 14:1212736.

PMID: 37359537 PMC: 10288977. DOI: 10.3389/fimmu.2023.1212736.

The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction.

Alfian I, Chakraborty A, Yong H, Saini S, Lau R, Kalionis B Cells. 2022; 11(9).

PMID: 35563719 PMC: 9102093. DOI: 10.3390/cells11091413.

The Role of Danger Associated Molecular Patterns in Human Fetal Membrane Weakening.

Padron J, Saito Reis C, Kendal-Wright C Front Physiol. 2020; 11:602.

PMID: 32625109 PMC: 7311766. DOI: 10.3389/fphys.2020.00602.

Inflammasomes: Their Role in Normal and Complicated Pregnancies.

Gomez-Lopez N, Motomura K, Miller D, Garcia-Flores V, Galaz J, Romero R J Immunol. 2019; 203(11):2757-2769.

PMID: 31740550 PMC: 6871659. DOI: 10.4049/jimmunol.1900901.

Expression and Clinical Significance of NOD-Like Receptor Protein 3 (NLRP3) and Caspase-1 in Fetal Membrane and Placental Tissues of Patients with Premature Rupture of Membrane.

Zhu J, He M, Ma C, Peng F, Su Y, Huang L Med Sci Monit. 2018; 24:1560-1566.

PMID: 29545514 PMC: 5868681. DOI: 10.12659/msm.906157.

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