Neuropsychological Performance in Polyconsumer Men Under Treatment. Influence of Age of Onset of Substance Use

Overview

Journal Sci Rep

Specialty Science

Date 2015 Jul 10

PMID 26155725

Citations 14

Authors

Maria Del Mar Capella

Irina Benaiges

Ana Adan

Affiliations

Soon will be listed here.

Abstract

Neurocognition is a key factor in the development and maintenance of Substance Use Disorders (SUD). However, there are still several aspects that need to be studied in this area. In this study, we elucidate the influence of age of onset of substance use (OSU) on the clinical course and neuropsychological performance of substance use disorder (SUD) patients, as well as to explore the influence of years of education, duration of drug use and premorbid intelligence quotient (IQ) on the cognitive results obtained. An exhaustive neuropsychological battery was used to assess different cognitive domains in 80 male polyconsumers, 41 with earlier OSU (16 years or before: OSU ≤ 16) and 39 with later OSU (17 years or later: OSU ≥ 17). The patients were under treatment with at least 4 months of abstinence confirmed by urinalysis. The OSU ≤ 16 group presented a worse clinical state, as well as a lower premorbid IQ and worse performance in processing speed, visual perception and planning skills. The duration of drug use may account for the differences in planning and processing speed. In this work we discuss the premorbid or acquired nature of the cognitive deficits found.

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References

Pedrero Perez E, Ruiz Sanchez de Leon J, Olivar Arroyo A, Rojo Mota G, Llanero Luque M, Puerta Garcia C . [Personality differences between alcohol abusers and matched controls: Relation to frontal symptoms and subtypes of addicts]. Psicothema. 2011; 23(1):100-6. View

Grant D, BERG E . A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. J Exp Psychol. 1948; 38(4):404-11. DOI: 10.1037/h0059831. View

Kreek M, Levran O, Reed B, Schlussman S, Zhou Y, Butelman E . Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. J Clin Invest. 2012; 122(10):3387-93. PMC: 3534165. DOI: 10.1172/JCI60390. View

Vanderploeg R, Schinka J . Predicting WAIS-R IQ premorbid ability: combining subtest performance and demographic variable predictors. Arch Clin Neuropsychol. 1995; 10(3):225-39. View

Liu X, Matochik J, Cadet J, London E . Smaller volume of prefrontal lobe in polysubstance abusers: a magnetic resonance imaging study. Neuropsychopharmacology. 1998; 18(4):243-52. DOI: 10.1016/S0893-133X(97)00143-7. View

Streeter C, Terhune D, Whitfield T, Gruber S, Sarid-Segal O, Silveri M . Performance on the Stroop predicts treatment compliance in cocaine-dependent individuals. Neuropsychopharmacology. 2007; 33(4):827-36. DOI: 10.1038/sj.npp.1301465. View

Palmer R, Young S, Hopfer C, Corley R, Stallings M, Crowley T . Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk. Drug Alcohol Depend. 2009; 102(1-3):78-87. PMC: 2746112. DOI: 10.1016/j.drugalcdep.2009.01.012. View

Lim K, Wozniak J, Mueller B, Franc D, Specker S, Rodriguez C . Brain macrostructural and microstructural abnormalities in cocaine dependence. Drug Alcohol Depend. 2007; 92(1-3):164-72. PMC: 2693223. DOI: 10.1016/j.drugalcdep.2007.07.019. View

Pope Jr H, Gruber A, Hudson J, Cohane G, Huestis M, Yurgelun-Todd D . Early-onset cannabis use and cognitive deficits: what is the nature of the association?. Drug Alcohol Depend. 2003; 69(3):303-10. DOI: 10.1016/s0376-8716(02)00334-4. View

10.

Cloninger C . Neurogenetic adaptive mechanisms in alcoholism. Science. 1987; 236(4800):410-6. DOI: 10.1126/science.2882604. View

11.

Benaiges I, Serra-Grabulosa J, Prat G, Adan A . Executive functioning in individuals with schizophrenia and/or cocaine dependence. Hum Psychopharmacol. 2012; 28(1):29-39. DOI: 10.1002/hup.2279. View

12.

Schweinsburg A, Schweinsburg B, Nagel B, Eyler L, Tapert S . Neural correlates of verbal learning in adolescent alcohol and marijuana users. Addiction. 2010; 106(3):564-73. PMC: 3423457. DOI: 10.1111/j.1360-0443.2010.03197.x. View

13.

Sundram S . Cannabis and neurodevelopment: implications for psychiatric disorders. Hum Psychopharmacol. 2006; 21(4):245-54. DOI: 10.1002/hup.762. View

14.

Johnson B, Cloninger C, Roache J, Bordnick P, Ruiz P . Age of onset as a discriminator between alcoholic subtypes in a treatment-seeking outpatient population. Am J Addict. 2000; 9(1):17-27. DOI: 10.1080/10550490050172191. View

15.

McGue M, Iacono W, Legrand L, Malone S, Elkins I . Origins and consequences of age at first drink. I. Associations with substance-use disorders, disinhibitory behavior and psychopathology, and P3 amplitude. Alcohol Clin Exp Res. 2001; 25(8):1156-65. View

16.

Fernandez-Serrano M, Perez-Garcia M, Rio-Valle J, Verdejo-Garcia A . Neuropsychological consequences of alcohol and drug abuse on different components of executive functions. J Psychopharmacol. 2009; 24(9):1317-32. DOI: 10.1177/0269881109349841. View

17.

Weiland B, Nigg J, Welsh R, Yau W, Zubieta J, Zucker R . Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood. Alcohol Clin Exp Res. 2012; 36(8):1355-64. PMC: 3412943. DOI: 10.1111/j.1530-0277.2012.01741.x. View

18.

Mohamed S, Bondi M, Kasckow J, Golshan S, Jeste D . Neurocognitive functioning in dually diagnosed middle aged and elderly patients with alcoholism and schizophrenia. Int J Geriatr Psychiatry. 2006; 21(8):711-8. DOI: 10.1002/gps.1528. View

19.

Kosten T, OConnor P . Management of drug and alcohol withdrawal. N Engl J Med. 2003; 348(18):1786-95. DOI: 10.1056/NEJMra020617. View

20.

Heatherton T, Kozlowski L, Frecker R, Fagerstrom K . The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict. 1991; 86(9):1119-27. DOI: 10.1111/j.1360-0443.1991.tb01879.x. View