Histone Deacetylases: Targets for Antifungal Drug Development

Overview

Journal Virulence

Specialty Microbiology

Date 2015 Jul 8

PMID 26151486

Citations 4

Authors

Livia Kmetzsch

Affiliations

Soon will be listed here.

Abstract

The interaction of pathogens and its hosts causes a drastic change in the transcriptional landscape in both cells. Among the several mechanisms of gene regulation, transcriptional initiation is probably the main point. In such scenario, the access of transcriptional machinery to promoter is highly regulated by post-translational modification of histones, such as acetylation, phosphorylation and others. Inhibition of histone deacetylases is able to reduce fungal pathogens fitness during infection and, therefore, is currently being considered for the development of new antifungal therapy strategies.

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