Hymenoptera Anaphylaxis and C-kit Mutations: An Unexpected Association

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2015 Jul 8

PMID 26149588

Citations 3

Authors

Patrizia Bonadonna

Massimiliano Bonifacio

Carla Lombardo

Roberta Zanotti

Affiliations

Soon will be listed here.

Abstract

Clinical manifestations of mastocytosis in adults comprise signs and symptoms linked to mast cell (MC) activation, including anaphylaxis. Depending on MC burden, adults can be diagnosed with systemic mastocytosis, when the WHO criteria are fulfilled, or with other clonal MC disorders, characterized by MC mediator symptoms and demonstration of activating KIT mutations and/or expression of CD25 on MCs. There is a specific link between mastocytosis and hymenoptera venom allergy (HVA): the reported frequency of HVA in mastocytosis is 20-50 % and raises to 60-80 % in patients affected by indolent systemic mastocytosis without skin lesions. The presentation of HVA characterized by severe hypotension in the absence of urticarial or angioedema is typical in patient with an underlying MC disorder, even in the presence of normal baseline serum tryptase levels.

Citing Articles

Current practices in diagnosis of Hymenoptera venom allergy in Poland.

Cichocka-Jarosz E, Brzyski P, Jedynak-Wasowicz U, Nittner-Marszalska M Postepy Dermatol Alergol. 2023; 38(2):222-229.

PMID: 36751544 PMC: 9880773. DOI: 10.5114/ada.2021.106200.

Microarray-Based Detection of Allergen-Reactive IgE in Patients with Mastocytosis.

Smiljkovic D, Kiss R, Lupinek C, Hoermann G, Greiner G, Witzeneder N J Allergy Clin Immunol Pract. 2020; 8(8):2761-2768.e16.

PMID: 32348913 PMC: 7116130. DOI: 10.1016/j.jaip.2020.04.030.

Component Resolved Diagnosis in Hymenoptera Anaphylaxis.

Tomsitz D, Brockow K Curr Allergy Asthma Rep. 2017; 17(6):38.

PMID: 28501976 DOI: 10.1007/s11882-017-0707-0.

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