Dissecting the Role of Smooth Muscle Cells Versus Pericytes in Regulating Cerebral Blood Flow Using In Vivo Optical Imaging
Overview
Affiliations
The brain regulates blood flow to match energy demand to nutrient supply. In this issue of Neuron, using in vivo optical imaging and optogenetics, Hill et al. (2015) report that arteriolar smooth muscle cells are key players in regulating cerebral blood flow in the healthy state and contribute to the "no reflow" phenomenon after ischemic stroke.
Polimeni J, Lewis L Prog Neurobiol. 2021; 207:102174.
PMID: 34525404 PMC: 8688322. DOI: 10.1016/j.pneurobio.2021.102174.
Cardiac pericytes function as key vasoactive cells to regulate homeostasis and disease.
Lee L, Khakoo A, Chintalgattu V FEBS Open Bio. 2020; 11(1):207-225.
PMID: 33135334 PMC: 7780101. DOI: 10.1002/2211-5463.13021.
de Montgolfier O, Thorin-Trescases N, Thorin E Am J Hypertens. 2020; 33(5):375-390.
PMID: 32202623 PMC: 7188799. DOI: 10.1093/ajh/hpaa001.
Using miniature brain implants in rodents for novel drug discovery.
Waldau B Expert Opin Drug Discov. 2019; 14(4):379-386.
PMID: 30831040 PMC: 9484820. DOI: 10.1080/17460441.2019.1577816.
Optical imaging and modulation of neurovascular responses.
Masamoto K, Vazquez A J Cereb Blood Flow Metab. 2018; 38(12):2057-2072.
PMID: 30334644 PMC: 6282226. DOI: 10.1177/0271678X18803372.