Prefrontal and Striatal Glutamate Differently Relate to Striatal Dopamine: Potential Regulatory Mechanisms of Striatal Presynaptic Dopamine Function?

Overview

Journal J Neurosci

Specialty Neurology

Date 2015 Jul 3

PMID 26134644

Citations 30

Authors

Tobias Gleich

Lorenz Deserno

Robert Christian Lorenz

Rebecca Boehme

Anne Pankow

Ralph Buchert

Simone Kuhn

Andreas Heinz

Florian Schlagenhauf

Jurgen Gallinat

Affiliations

Soon will be listed here.

Abstract

Significance Statement: The present work demonstrates complementary relationships between prefrontal and striatal glutamate and ventral striatal presynaptic dopamine using human imaging measures: a negative correlation between prefrontal glutamate and presynaptic dopamine and a positive relationship between striatal glutamate and presynaptic dopamine are revealed. The results may reflect a regulatory role of prefrontal and striatal glutamate for ventral striatal presynaptic dopamine levels. Such glutamate-dopamine relationships improve our understanding of neurochemical interactions in prefrontostriatal circuits and have implications for the neurobiology of mental disease.

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