Therapeutic Effects of Bee Venom on Immunological and Neurological Diseases

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2015 Jul 2

PMID 26131770

Citations 33

Authors

Deok-Sang Hwang

Sun Kwang Kim

Hyunsu Bae

Affiliations

Soon will be listed here.

Abstract

Bee Venom (BV) has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid arthritis. The underlying mechanisms of the anti-inflammatory and analgesic actions of BV have been proved to some extent. Additionally, recent clinical and experimental studies have demonstrated that BV and BV-derived active components are applicable to a wide range of immunological and neurodegenerative diseases, including autoimmune diseases and Parkinson's disease. These effects of BV are known to be mediated by modulating immune cells in the periphery, and glial cells and neurons in the central nervous system. This review will introduce the scientific evidence of the therapeutic effects of BV and its components on several immunological and neurological diseases, and describe their detailed mechanisms involved in regulating various immune responses and pathological changes in glia and neurons.

Citing Articles

Shedding Light on the Antioxidant Activity of Bee Venom Using a 2,2-Diphenyl-1-Picrylhydrazyl Assay in a Detergent-Based Buffer.

Orru A, Pittau B, Pettinau F Molecules. 2025; 30(3).

PMID: 39942743 PMC: 11821050. DOI: 10.3390/molecules30030640.

Low-dose Bee Venom as a Potential Therapeutic Agent Against Human Chronic Myeloid Leukaemia Cells.

Halici H, Un H, Celik S, Karakoy Z, Bayraktutan Z, Ozlu C Protein J. 2025; .

PMID: 39924635 DOI: 10.1007/s10930-025-10251-2.

Melittin - the main component of bee venom: a promising therapeutic agent for neuroprotection through keap1/Nrf2/HO-1 pathway activation.

Nguyen C, Yoo J, Jeong S, Ha H, Yang J, Lee G Chin Med. 2024; 19(1):166.

PMID: 39605070 PMC: 11603938. DOI: 10.1186/s13020-024-01020-x.

Therapeutic Potential of Bee and Wasp Venom in Anti-Arthritic Treatment: A Review.

Sun H, Qu Y, Lei X, Xu Q, Li S, Shi Z Toxins (Basel). 2024; 16(11).

PMID: 39591207 PMC: 11598298. DOI: 10.3390/toxins16110452.

Heterologous expressing melittin in a probiotic yeast to evaluate its function for promoting NSC-34 regeneration.

Huang H, Hsu H, Kuo C, Wu M, Lai C, Chang G Appl Microbiol Biotechnol. 2024; 108(1):496.

PMID: 39466458 PMC: 11519230. DOI: 10.1007/s00253-024-13336-7.

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