Association Between Serum Carcinoembryonic Antigen Level and Oxidative Stress Parameters Among Diabetic Females

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2015 Jul 2

PMID 26131277

Citations 13

Authors

Marghoob Hasan

Abdelmarouf Mohieldein

Affiliations

Soon will be listed here.

Abstract

Unlabelled: In this study we intended to determine serum level of the carcinoembryonic antigen (CEA) and to find out the correlation with oxidative stress parameters among diabetic female in comparison to control subjects.

Methods: A total of 120 Saudi (type 2 diabetic "T2DM", n = 60 and healthy non-diabetic, n = 60) nonsmokers females were enrolled in this study. Body mass index (BMI) was estimated using weight and height; CEA, superoxide dismutase (SOD), 8-hydroxy-deoxyguanosine (8-OHDG), malondialdehyde (MDA) were performed using enzyme-linked immunosorbent assay (ELISA) kits. Blood glucose was estimated by GOD/POD method and, glycated haemoglobin (HbA1c) by immunoturbidimetric method.

Results: The student's t-test showed significant differences between the diabetics and controls in CEA, blood glucose, age, oxidative stress markers. Moreover, Pearson's correlation coefficient (r) indicated significant correlations between CEA and age, BMI, blood glucose, HbA1, and MDA. No significant correlation was found between CEA and 8-OHdG, SOD.

Conclusions: In this study we confirmed that CEA influence with components of type 2 diabetes and glycemic control. We found correlation between Lipid peroxidation and CEA among diabetic female in comparison to control subjects.

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References

Niedernhofer L, Daniels J, Rouzer C, Greene R, Marnett L . Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem. 2003; 278(33):31426-33. DOI: 10.1074/jbc.M212549200. View

Chen P, Lin H . Reversible high blood CEA and CA19-9 concentrations in a diabetic patient. Libyan J Med. 2012; 7. PMC: 3480960. DOI: 10.3402/ljm.v7i0.19572. View

van Greevenbroek M, Schalkwijk C, Stehouwer C . Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences. Neth J Med. 2013; 71(4):174-87. View

Ishizaka N, Ishizaka Y, Toda E, Koike K, Yamakado M, Nagai R . Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men?. Arterioscler Thromb Vasc Biol. 2007; 28(1):160-5. DOI: 10.1161/ATVBAHA.107.155465. View

Bae U, Shim J, Lee H, Shin J . Serum carcinoembryonic antigen level is associated with arterial stiffness in healthy Korean adult. Clin Chim Acta. 2012; 415:286-9. DOI: 10.1016/j.cca.2012.10.052. View

Shinde S, Dhadke V, Suryakar A . Evaluation of Oxidative Stress in Type 2 Diabetes Mellitus and Follow-up Along with Vitamin E Supplementation. Indian J Clin Biochem. 2012; 26(1):74-7. PMC: 3068769. DOI: 10.1007/s12291-010-0041-y. View

Wright Jr E, Scism-Bacon J, GLASS L . Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract. 2006; 60(3):308-14. PMC: 1448694. DOI: 10.1111/j.1368-5031.2006.00825.x. View

Muti P, Quattrin T, Grant B, Krogh V, Micheli A, Schunemann H . Fasting glucose is a risk factor for breast cancer: a prospective study. Cancer Epidemiol Biomarkers Prev. 2002; 11(11):1361-8. View

Kim K, Joo N, Je S, Kim K, Kim B, Park S . Carcinoembryonic antigen level can be overestimated in metabolic syndrome. J Korean Med Sci. 2011; 26(6):759-64. PMC: 3102869. DOI: 10.3346/jkms.2011.26.6.759. View

10.

Stattin P, Bjor O, Ferrari P, Lukanova A, Lenner P, Lindahl B . Prospective study of hyperglycemia and cancer risk. Diabetes Care. 2007; 30(3):561-7. DOI: 10.2337/dc06-0922. View

11.

Donath M, Ehses J, Maedler K, Schumann D, Ellingsgaard H, Eppler E . Mechanisms of beta-cell death in type 2 diabetes. Diabetes. 2005; 54 Suppl 2:S108-13. DOI: 10.2337/diabetes.54.suppl_2.s108. View

12.

Alexiou D, Karayiannakis A, Syrigos K, Zbar A, Kremmyda A, Bramis I . Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery. Eur J Cancer. 2001; 37(18):2392-7. DOI: 10.1016/s0959-8049(01)00318-5. View

13.

Lee J, Lee H, Lee D, Lee J . Serum carcinoembryonic antigen is associated with abdominal visceral fat accumulation in female Korean nonsmokers. PLoS One. 2012; 7(8):e43518. PMC: 3428363. DOI: 10.1371/journal.pone.0043518. View

14.

Ayala A, Munoz M, Arguelles S . Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014; 2014:360438. PMC: 4066722. DOI: 10.1155/2014/360438. View

15.

Giacco F, Brownlee M . Oxidative stress and diabetic complications. Circ Res. 2010; 107(9):1058-70. PMC: 2996922. DOI: 10.1161/CIRCRESAHA.110.223545. View

16.

Thomas P, Toth C, Saini K, Jessup J, Steele Jr G . The structure, metabolism and function of the carcinoembryonic antigen gene family. Biochim Biophys Acta. 1990; 1032(2-3):177-89. DOI: 10.1016/0304-419x(90)90003-j. View

17.

Park J, Kim H, Park H, Kim C, Kim T . Efficient induction of anti-tumor immunity by a TAT-CEA fusion protein vaccine with poly(I:C) in a murine colorectal tumor model. Vaccine. 2011; 29(47):8642-8. DOI: 10.1016/j.vaccine.2011.09.052. View

18.

Pickup J . Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004; 27(3):813-23. DOI: 10.2337/diacare.27.3.813. View

19.

Gur T, Demir H, Kotan M . Tumor markers and biochemical parameters in colon cancer patients before and after chemotherapy. Asian Pac J Cancer Prev. 2012; 12(11):3147-50. View

20.

Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners C . Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell. 1989; 57(2):327-34. DOI: 10.1016/0092-8674(89)90970-7. View