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Autologous Vaccination for the Treatment of Equine Sarcoids: 18 Cases (2009-2014)

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Journal Can Vet J
Date 2015 Jul 2
PMID 26130832
Citations 7
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Abstract

The purpose of this retrospective case series was to assess the outcome of an autologous vaccination procedure on single and multiple sarcoid lesions, determine complication rate, and report owner satisfaction. Medical records (18 cases) from January 2009 through May 2014 were evaluated to identify horses undergoing the procedure. Signalment, number, size, anatomic location of lesions, and type of historical treatment were recorded. Follow-up was obtained via standardized owner survey, veterinary examination, and digital images. Data recorded and analyzed included ancillary therapies post-procedure, decrease in number and/or size of sarcoid lesions, sarcoid regrowth, complications, and owner satisfaction. There was a decrease in number of lesions observed by owners in 75% of cases and a decrease in size of sarcoids in 93.8% of cases. Clinical regression observed by owners was noted in 68.8% of cases. There were complications in 43.8% of cases and owner satisfaction in 75% of cases.

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References
1.
van Poelgeest M, Welters M, van Esch E, Stynenbosch L, Kerpershoek G, van Persijn van Meerten E . HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial. J Transl Med. 2013; 11:88. PMC: 3623745. DOI: 10.1186/1479-5876-11-88. View

2.
Paillot R . A systematic review of the immune-modulators Parapoxvirus ovis and Propionibacterium acnes for the prevention of respiratory disease and other infections in the horse. Vet Immunol Immunopathol. 2013; 153(1-2):1-9. DOI: 10.1016/j.vetimm.2013.01.010. View

3.
Vici P, Mariani L, Pizzuti L, Sergi D, Di Lauro L, Vizza E . Immunologic treatments for precancerous lesions and uterine cervical cancer. J Exp Clin Cancer Res. 2014; 33:29. PMC: 3986944. DOI: 10.1186/1756-9966-33-29. View

4.
Meredith D, Elser A, Wolf B, Soma L, Donawick W, Lazary S . Equine leukocyte antigens: relationships with sarcoid tumors and laminitis in two pure breeds. Immunogenetics. 1986; 23(4):221-5. DOI: 10.1007/BF00373016. View

5.
Vanselow B, Abetz I, Jackson A . BCG emulsion immunotherapy of equine sarcoid. Equine Vet J. 1988; 20(6):444-7. DOI: 10.1111/j.2042-3306.1988.tb01571.x. View