An Urgent Need for Experimental Animal Model of Autism in Drug Development

Overview

Journal Ann Neurosci

Publisher Sage Publications

Specialty Neurology

Date 2015 Jul 1

PMID 26124551

Citations 12

Authors

Rakesh K Ruhela

Ajay Prakash

Bikash Medhi

Affiliations

Soon will be listed here.

Abstract

Construct, face and predictive validities are necessary for any disease model. Although rodent models are used to investigate the neurobiology of autism, however, till date there is no such ideal animal model which can fulfill all the above said validities. Available drug therapy to treat autism is very limited and less effective. In this review, we summarize the work done with rodent models of autism and highlight different validities. We found that, very few studies have studied all the validities in a single study and none of the study fulfilled all the validities. We also reviewed the drugs used in the treatment of autism. Here we propose the limitations of available animal models. We also propose the urgent need of additional models to fulfill all the validities and to understand autism in a better way.

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