Elevated Level of Renal Xanthine Oxidase MRNA Transcription After Nephropathogenic Infectious Bronchitis Virus Infection in Growing Layers

Overview

Journal J Vet Sci

Specialty Veterinary Medicine

Date 2015 Jun 30

PMID 26119168

Citations 6

Authors

Huayuan Lin

Qiqi Huang

Xiaoquan Guo

Ping Liu

Weilian Liu

Yuelong Zou

Shuliang Zhu

Guangfu Deng

Jun Kuang

Caiying Zhang

Huabin Cao

Guoliang Hu

Affiliations

Soon will be listed here.

Abstract

To assess relationships between xanthine oxidase (XOD) and nephropathogenic infectious bronchitis virus (NIBV) infection, 240 growing layers (35 days old) were randomly divided into two groups (infected and control) of 120 chickens each. Each chicken in the control and infected group was intranasally inoculated with 0.2 mL sterile physiological saline and virus, respectively, after which serum antioxidant parameters and renal XOD mRNA expression in growing layers were evaluated at 8, 15 and 22 days post-inoculation (dpi). The results showed that serum glutathione peroxidase and superoxide dismutase activities in the infected group were significantly lower than in the control group at 8 and 15 dpi (p < 0.01), while serum malondialdehyde concentrations were significantly higher (p < 0.01). The serum uric acid was significantly higher than that of the control group at 15 dpi (p < 0.01). In addition, the kidney mRNA transcript level and serum activity of XOD in the infected group was significantly higher than that of the control group at 8, 15 and 22 dpi (p < 0.05). The results indicated that NIBV infection could cause the increases of renal XOD gene transcription and serum XOD activity, leading to hyperuricemia and reduction of antioxidants in the body.

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