Isolation and Immunomodulatory Activity of Bursal Peptide, a Novel Bursal Peptide from the Chicken Bursa of Fabricius

Overview

Journal J Vet Sci

Specialty Veterinary Medicine

Date 2015 Jun 30

PMID 26119163

Citations 3

Authors

Xiao-Dong Liu

Yingjuan Qian

Yong-Sam Jung

Pu-Yan Chen

Affiliations

Soon will be listed here.

Abstract

The bursa of Fabricius (BF), which is unique to birds, serves as the central humoral immune organ and plays a significant role in B lymphocyte differentiation. In this study, a new bursal peptide (BP-IV) was isolated from BF, which promoted colony-forming unit pre-B formation and regulated B cell differentiation. BP-IV also exerted immunomodulatory effects on antigen-specific immune responses via both humoral and cellular immunity in chicken and mice that had been immunized with inactivated avian influenza virus (AIV; H9N2 subtype), including enhancing AIV-specific antibody and cytokine production. The results of this study provided novel insights into the use of a potential candidate reagent for B cell development and future immuno-pharmacological use.

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