[GENETIC ASPECTS OF CHRONIC GLOMERULONEPHRITIS]

The aim of our work was to determine the the gene polymorphism of IL-1β in children with chronic glomerulonephritis. there has been defined the frequency of combinations of allelic variants of cytokines genes of IL-1β and IL-10 in chronic glomerulonephritis in children and found the connection of allelic polymorphism with the disease course, indices of hemopoiesis and IL-1β in serum. The presence of C/T genotype is associated with increased production of interleukin-1β in serum. Genetic polymorphism of genes of interleukin can be a new marker of progression of chronic kidney disease.