The Association Between Obstructive Sleep Apnea and Metabolic Markers and Lipid Profiles

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Jun 27

PMID 26115005

Citations 18

Authors

Wei-Te Wu

Su-Shan Tsai

Tung-Sheng Shih

Ming-Hsiu Lin

Tzu-Chieh Chou

Hua Ting

Trong-Neng Wu

Saou-Hsing Liou

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of this study was to investigate the association between apnea-hypopnea index (AHI) and metabolic markers and whether the elevated risk of Metabolic Syndrome (MetS) is related to Obstructive Sleep Apnea (OSA).

Methods: This cross-sectional study recruited 246 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test and by blood lipids examination. Severity of OSA was categorized according to the apnea-hypopnea index (AHI).

Results: The results showed that a 73.3% prevalence of MetS in OSA (AHI > 15) and a 80.0% prevalence of MetS in severe OSA (AHI > 30) were found. After adjusting for confounding variables, an increased level of Body-Mass Index (BMI) and two non-MetS cardiovascular risk factors, total cholesterol/HDL-C ratio and TG/HDL-C ratio was significantly associated with AHI in subjects with severe OSA. MetS was about three times to be present in subjects with severe OSA, even adjusted for BMI.

Conclusions: The findings showed a high prevalence of MetS in OSA among professional drivers, especially in the severe group category. BMI was the major contributing factor to OSA. However, the present study did not find a sensitive clinical marker of a detrimental metabolic profile in OSA patients.

Citing Articles

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Composite lipid indices in patients with obstructive sleep apnea: a systematic review and meta-analysis.

Behnoush A, Bahiraie P, Shokri Varniab Z, Foroutani L, Khalaji A Lipids Health Dis. 2023; 22(1):84.

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Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.

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