Association Between DRD2/ANKK1 TaqIA Polymorphism and Susceptibility with Tourette Syndrome: A Meta-Analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Jun 26

PMID 26110876

Citations 7

Authors

Aihua Yuan

Liang Su

Shunying Yu

ChunBo Li

Tao Yu

Jinhua Sun

Affiliations

Soon will be listed here.

Abstract

Background: Genetic factors are important in the pathogenesis of Tourette syndrome (TS). Notably, Dopamine receptor D2 (DRD2) gene has been suggested as a possible candidate gene for this disorder. Several studies have demonstrated that DRD2/ANKK1 TaqIA polymorphism is associated with an increased risk of developing TS. However, past results remain conflicting. We addressed this controversy by performing a meta-analysis of the relationship between DRD2/ANKK1 TaqIA polymorphism and TS.

Methods: Literature was searched in multiple databases including PUBMED, COCHRANE and WEB OF SCIENCE up to July 2014. The number of the genotypes for DRD2/ANKK1 TaqIA in the TS and control subjects was extracted and statistical analysis was performed using Review Manager 5.0.16 and Stata 12.0 software. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were utilized to calculate the risk of TS with DRD2/ANKK1 TaqIA. Stratified analysis based on ethnicity was also conducted.

Results: 523 patients with TS, 564 controls and 87 probands plus 152 relatives from five published studies were finally involved in this meta-analysis. Combined analysis revealed that the overall ORs for the DRD2/ANKK1 TaqIA A1 allele were 1.69 (95%CIs = 1.42-2.00) in the fixed-effect model and 1.66 (95%CIs = 1.33-2.08) in the random-effects model. Stratification by ethnicity indicated the TaqIA A1 allele was significantly associated with TS in Caucasians (fixed-effect model: OR=1.75, 95%CI = 1.43-2.16; random-effect model: OR=1.69, 95%CI = 1.25-2.28) and in Asians (OR=1.54, 95%CI = 1.12-2.10). Meta-analysis of the A1A1 vs. A2A2 (homozygous model), A1A2 vs. A2A2 (heterozygous model) and A1A1+A1A2 vs. A2A2 (dominant model) of this polymorphism revealed a significant association with TS in overall populations and Caucasians.

Conclusions: This meta-analysis suggested that the DRD2/ANKK1 TaqIA polymorphism might contribute to TS susceptibility, especially in Caucasian population. However, further investigation with a larger number of worldwide studies should be conducted to verify the association.

Citing Articles

Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year.

Thanos P, Hanna C, Mihalkovic A, Hoffman A, Posner A, Butsch J Biomedicines. 2023; 11(10).

PMID: 37893019 PMC: 10603884. DOI: 10.3390/biomedicines11102644.

Candidate Genes and Pathways Associated with Gilles de la Tourette Syndrome-Where Are We?.

Levy A, Paschou P, Tumer Z Genes (Basel). 2021; 12(9).

PMID: 34573303 PMC: 8468358. DOI: 10.3390/genes12091321.

Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors.

Blum K, Gondre-Lewis M, Baron D, Thanos P, Braverman E, Neary J Front Psychiatry. 2018; 9:548.

PMID: 30542299 PMC: 6277779. DOI: 10.3389/fpsyt.2018.00548.

Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats.

Nespoli E, Rizzo F, Boeckers T, Schulze U, Hengerer B PLoS One. 2018; 13(4):e0196515.

PMID: 29698507 PMC: 5919623. DOI: 10.1371/journal.pone.0196515.

BDNF and LTP-/LTD-like plasticity of the primary motor cortex in Gilles de la Tourette syndrome.

Marsili L, Suppa A, Di Stasio F, Belvisi D, Upadhyay N, Berardelli I Exp Brain Res. 2016; 235(3):841-850.

PMID: 27900437 DOI: 10.1007/s00221-016-4847-6.

References

Lv H, Lin H, Zhao H, Li A, Lin Y, Yao B . Effects of ningdong granule on DA, DRD2, and HVA in a rat model of Tourette's syndrome. J Tradit Chin Med. 2012; 32(2):283-8. DOI: 10.1016/s0254-6272(13)60026-6. View

Gunther J, Tian Y, Stamova B, Lit L, Corbett B, Ander B . Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome. Psychiatry Res. 2012; 200(2-3):593-601. DOI: 10.1016/j.psychres.2012.04.034. View

Scharf J, Yu D, Mathews C, Neale B, Stewart S, Fagerness J . Genome-wide association study of Tourette's syndrome. Mol Psychiatry. 2012; 18(6):721-8. PMC: 3605224. DOI: 10.1038/mp.2012.69. View

Paschou P . The genetic basis of Gilles de la Tourette Syndrome. Neurosci Biobehav Rev. 2013; 37(6):1026-39. DOI: 10.1016/j.neubiorev.2013.01.016. View

Kurlan R . Treatment of Tourette syndrome. Neurotherapeutics. 2013; 11(1):161-5. PMC: 3899474. DOI: 10.1007/s13311-013-0215-4. View

Robertson M . Tourette syndrome, associated conditions and the complexities of treatment. Brain. 2000; 123 Pt 3:425-62. DOI: 10.1093/brain/123.3.425. View

Sterne J, Gavaghan D, Egger M . Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol. 2000; 53(11):1119-29. DOI: 10.1016/s0895-4356(00)00242-0. View

Simonic I, Nyholt D, Gericke G, Gordon D, Matsumoto N, Ledbetter D . Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners. Am J Med Genet. 2001; 105(2):163-7. DOI: 10.1002/ajmg.1192. View

Peterson B, Pine D, Cohen P, Brook J . Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample. J Am Acad Child Adolesc Psychiatry. 2001; 40(6):685-95. DOI: 10.1097/00004583-200106000-00014. View

10.

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

11.

Sandor P . Pharmacological management of tics in patients with TS. J Psychosom Res. 2003; 55(1):41-8. DOI: 10.1016/s0022-3999(03)00060-6. View

12.

Minzer K, Lee O, Hong J, Singer H . Increased prefrontal D2 protein in Tourette syndrome: a postmortem analysis of frontal cortex and striatum. J Neurol Sci. 2004; 219(1-2):55-61. DOI: 10.1016/j.jns.2003.12.006. View

13.

Diaz-Anzaldua A, Joober R, Riviere J, Dion Y, Lesperance P, Richer F . Tourette syndrome and dopaminergic genes: a family-based association study in the French Canadian founder population. Mol Psychiatry. 2004; 9(3):272-7. DOI: 10.1038/sj.mp.4001411. View

14.

Nee L, Caine E, Polinsky R, Eldridge R, EBERT M . Gilles de la Tourette syndrome: clinical and family study of 50 cases. Ann Neurol. 1980; 7(1):41-9. DOI: 10.1002/ana.410070109. View

15.

Kidd K, Prusoff B, Cohen D . Familial pattern of Gilles de la Tourette syndrome. Arch Gen Psychiatry. 1980; 37(12):1336-9. DOI: 10.1001/archpsyc.1980.01780250022001. View

16.

Price R, Kidd K, Cohen D, Pauls D, Leckman J . A twin study of Tourette syndrome. Arch Gen Psychiatry. 1985; 42(8):815-20. DOI: 10.1001/archpsyc.1985.01790310077011. View

17.

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

18.

Comings D, Comings B, Muhleman D, Dietz G, Shahbahrami B, Tast D . The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA. 1991; 266(13):1793-800. View

19.

Hyde T, Aaronson B, Randolph C, Rickler K, Weinberger D . Relationship of birth weight to the phenotypic expression of Gilles de la Tourette's syndrome in monozygotic twins. Neurology. 1992; 42(3 Pt 1):652-8. DOI: 10.1212/wnl.42.3.652. View

20.

. Definitions and classification of tic disorders. The Tourette Syndrome Classification Study Group. Arch Neurol. 1993; 50(10):1013-6. DOI: 10.1001/archneur.1993.00540100012008. View