Oxymatrine Ameliorates Renal Ischemia-reperfusion Injury from Oxidative Stress Through Nrf2/HO-1 Pathway

Overview

Journal Acta Cir Bras

Specialty General Surgery

Date 2015 Jun 25

PMID 26108031

Citations 28

Authors

Guanjun Jiang

Xiuheng Liu

Min Wang

Hui Chen

Zhiyuan Chen

Tao Qiu

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats and explore the possible role of oxymatrine in Nrf2/HO-1 pathway.

Methods: Unilaterally nephrectomized rats were insulted by I/R in their left kidney. Twenty four rats were randomly divided into three groups: sham group, I/R + saline-treated group, I/R + OMT-treated group. Oxymatrine or vehicle solution was administered intraperitoneally injected 60 min before renal ischemia, respectively. Renal function, histology, makers of oxidative stress, cell apoptosis and Nrf2/HO-1 expressions were assessed.

Results: Oxymatrine pretreatment exhibited an improved renal functional recovery, alleviated histological injury and oxidative stress, inhibiting tubular apoptosis, and accompanied by upregulated the expression of Nrf2/HO-1 proteins.

Conclusion: Oxymatrine may attenuate renal ischemia/reperfusion injury, and this renoprotective effect may be through activating the Nrf2/HO-1 pathway.

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