Synchronous Multicentric Giant Cell Tumour of Distal Radius and Sacrum with Pulmonary Metastases

Overview

Journal Case Rep Oncol Med

Publisher Wiley

Specialty Oncology

Date 2015 Jun 25

PMID 26106496

Citations 6

Authors

Varun Sharma Tandra

Krishna Mohan Reddy Kotha

Moorthy Gadisetti Venkata Satyanarayana

Kali Varaprasad Vadlamani

Vyjayanthi Yerravalli

Affiliations

Soon will be listed here.

Abstract

Giant cell tumour (GCT) is an uncommon primary bone tumour, and its multicentric presentation is exceedingly rare. We report a case of a 45-year-old female who presented to us with GCT of left distal radius. On the skeletal survey, osteolytic lesion was noted in her right sacral ala. Biopsy confirmed both lesions as GCT. Pulmonary metastasis was also present. Resection-reconstruction arthroplasty for distal radius and thorough curettage and bone grafting of the sacral lesion were done. Multicentric GCT involving distal radius and sacrum with primary sacral involvement is not reported so far to our knowledge.

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References

Park I, Jeon I . Multicentric giant cell tumor of bone: ten lesions at presentation. Skeletal Radiol. 2003; 32(9):526-9. DOI: 10.1007/s00256-003-0658-5. View

Bacchini P, Bertoni F, Ruggieri P, Campanacci M . Multicentric giant cell tumor of skeleton. Skeletal Radiol. 1995; 24(5):371-4. DOI: 10.1007/BF00197071. View

Park Y, Ryu K, Han C, Bae D . Multifocal, metachronous giant-cell tumor of the ulna. A case report. J Bone Joint Surg Am. 1999; 81(3):409-13. DOI: 10.2106/00004623-199903000-00015. View

Mondal A, Kundu B, Kundu R, Bhattacharya M . Multifocal giant cell tumour of bone in a skeletally immature patient--a case report. Indian J Pathol Microbiol. 2002; 44(4):479-81. View

Rousseau M, Ilharreborde B, Larousserie F, Babinet A, Tomeno B, Anract P . [Multicentric giant-cell tumor]. Rev Chir Orthop Reparatrice Appar Mot. 2008; 93(8):848-53. DOI: 10.1016/s0035-1040(07)78469-6. View

Sim F, Dahlin D, Beabout J . Multicentric giant-cell tumor of bone. J Bone Joint Surg Am. 1977; 59(8):1052-60. View

Stratil P, Stacy G . Multifocal metachronous giant cell tumor in a 15-year-old boy. Pediatr Radiol. 2004; 35(4):444-8. DOI: 10.1007/s00247-004-1346-x. View

Cummins C, Scarborough M, ENNEKING W . Multicentric giant cell tumor of bone. Clin Orthop Relat Res. 1996; (322):245-52. View

Peimer C, Schiller A, Mankin H, Smith R . Multicentric giant-cell tumor of bone. J Bone Joint Surg Am. 1980; 62(4):652-6. View

10.

Kos C, Taconis W, Fidler M, Ten Velden J . Multifocal giant cell tumors in the spine. A case report. Spine (Phila Pa 1976). 1997; 22(7):821-2. DOI: 10.1097/00007632-199704010-00022. View

11.

Shen C, Li H, Shi Z, Tao H, Yang Z . Current treatment of sacral giant cell tumour of bone: a review. J Int Med Res. 2012; 40(2):415-25. DOI: 10.1177/147323001204000203. View

12.

Eckardt J, Grogan T . Giant cell tumor of bone. Clin Orthop Relat Res. 1986; (204):45-58. View

13.

Dhillon M, Prasad P . Multicentric giant cell tumour of bone. Acta Orthop Belg. 2007; 73(3):289-99. View

14.

Haskell A, Wodowoz O, Johnston J . Metachronous multicentric giant cell tumor: a case report and literature review. Clin Orthop Relat Res. 2003; (412):162-8. DOI: 10.1097/01.blo.0000068770.86536.e1. View

15.

Balke M, Henrichs M, Gosheger G, Ahrens H, Streitbuerger A, Koehler M . Giant cell tumors of the axial skeleton. Sarcoma. 2012; 2012:410973. PMC: 3289906. DOI: 10.1155/2012/410973. View

16.

Dumford K, Moore T, Walker C, Jaksha J . Multifocal, metachronous, giant cell tumor of the lower limb. Skeletal Radiol. 2003; 32(3):147-50. DOI: 10.1007/s00256-002-0551-7. View

17.

Hoch B, Inwards C, Sundaram M, Rosenberg A . Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty cases. J Bone Joint Surg Am. 2006; 88(9):1998-2008. DOI: 10.2106/JBJS.E.01111. View