Selective Decontamination and Antibiotic Resistance in ICUs

Overview

Journal Crit Care

Specialty Critical Care

Date 2015 Jun 25

PMID 26104045

Citations 15

Authors

Nienke L Plantinga

Marc J M Bonten

Affiliations

Soon will be listed here.

Abstract

Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) have been associated with reduced mortality and lower ICU-acquired bacteremia and ventilator-associated pneumonia rates in areas with low levels of antibiotic resistance. However, the effect of selective decontamination (SDD/SOD) in areas where multidrug-resistant Gram-negative bacteria are endemic is less clear. It will be important to determine whether SDD/SOD improves patient outcome in such settings and how these measures affect the epidemiology of multidrug-resistant Gram-negative bacteria. Here we review the current evidence on the effects of SDD/SOD on antibiotic resistance development in individual ICU patients as well as the effect on ICU ecology, the latter including both ICU-level antibiotic resistance and antibiotic resistance development during long-term use of SDD/SOD.

Citing Articles

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Selective digestive tract decontamination to prevent healthcare associated infections in critically ill children: the PICNIC multicentre randomised pilot clinical trial.

Pathan N, Woolfall K, Popa M, de la Fuente G, Ferrando-Vivas P, Brown A Sci Rep. 2023; 13(1):21668.

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The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic.

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Oropharyngeal Decontamination for Prevention of VAP in Patients Admitted to Intensive Care Units: A Systematic Review.

Keykha A, Ramezani M, Amini S, Karimi Moonaghi H J Caring Sci. 2022; 11(3):178-187.

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Use of selective gut decontamination in critically ill children: protocol for the Paediatric Intensive Care and Infection Control (PICnIC) pilot study.

Brown A, Ferrando P, Popa M, de la Fuente G, Pappachan J, Cuthbertson B BMJ Open. 2022; 12(3):e061838.

PMID: 35277414 PMC: 8919465. DOI: 10.1136/bmjopen-2022-061838.

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