Physiological Roles of Connexins and Pannexins in Reproductive Organs

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2015 Jun 24

PMID 26100514

Citations 11

Authors

Mark Kibschull

Alexandra Gellhaus

Diane Carette

Dominique Segretain

Georges Pointis

Jerome Gilleron

Affiliations

Soon will be listed here.

Abstract

Reproductive organs are complex and well-structured tissues essential to perpetuate the species. In mammals, the male and female reproductive organs vary on their organization, morphology and function. Connectivity between cells in such tissues plays pivotal roles in organogenesis and tissue functions through the regulation of cellular proliferation, migration, differentiation and apoptosis. Connexins and pannexins can be seen as major regulators of these physiological processes. In the present review, we assembled several lines of evidence demonstrating that these two families of proteins are essential for male and female reproduction.

Citing Articles

Adipose-Derived Mesenchymal Stem Cell Transplantation in Chemotherapy-Induced Premature Ovarian Insufficiency: the Role of Connexin and Pannexin.

Sen Halicioglu B, Saadat K, Tuglu M Reprod Sci. 2021; 29(4):1316-1331.

PMID: 34449073 DOI: 10.1007/s43032-021-00718-9.

Connexin43 in Germ Cells Seems to Be Dispensable for Murine Spermatogenesis.

Rode K, Langeheine M, Seeger B, Brehm R Int J Mol Sci. 2021; 22(15).

PMID: 34360693 PMC: 8348783. DOI: 10.3390/ijms22157924.

Intrauterine exposure to diethylhexyl phthalate disrupts gap junctions in the fetal rat testis.

Di Lorenzo M, Boeg Winge S, Svingen T, De Falco M, Boberg J Curr Res Toxicol. 2021; 1:5-11.

PMID: 34345832 PMC: 8320622. DOI: 10.1016/j.crtox.2020.02.002.

Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26.

Garcia-Vega L, OShaughnessy E, Albuloushi A, Martin P Biology (Basel). 2021; 10(1).

PMID: 33466954 PMC: 7829877. DOI: 10.3390/biology10010059.

The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals.

Kordowitzki P, Kranc W, Bryl R, Kempisty B, Skowronska A, Skowronski M Cells. 2020; 9(12).

PMID: 33271827 PMC: 7760214. DOI: 10.3390/cells9122570.

References

Flechon J, Degrouard J, Flechon B, Lefevre F, Traub O . Gap junction formation and connexin distribution in pig trophoblast before implantation. Placenta. 2004; 25(1):85-94. DOI: 10.1016/j.placenta.2003.08.013. View

Richard S, Baltz J . Prophase I arrest of mouse oocytes mediated by natriuretic peptide precursor C requires GJA1 (connexin-43) and GJA4 (connexin-37) gap junctions in the antral follicle and cumulus-oocyte complex. Biol Reprod. 2014; 90(6):137. DOI: 10.1095/biolreprod.114.118505. View

Winterhager E, von Ostau C, Gerke M, Gruemmer R, Traub O, Kaufmann P . Connexin expression patterns in human trophoblast cells during placental development. Placenta. 1999; 20(8):627-38. DOI: 10.1053/plac.1999.0434. View

Zhang J, Zhang H, Zhang M, Qiu Z, Wu Y, Callaway D . Connexin43 hemichannels mediate small molecule exchange between chondrocytes and matrix in biomechanically-stimulated temporomandibular joint cartilage. Osteoarthritis Cartilage. 2014; 22(6):822-30. PMC: 4706739. DOI: 10.1016/j.joca.2014.03.017. View

Reaume A, Sousa P, Kulkarni S, Langille B, Zhu D, Davies T . Cardiac malformation in neonatal mice lacking connexin43. Science. 1995; 267(5205):1831-4. DOI: 10.1126/science.7892609. View

Lefebvre L . The placental imprintome and imprinted gene function in the trophoblast glycogen cell lineage. Reprod Biomed Online. 2012; 25(1):44-57. PMC: 3819294. DOI: 10.1016/j.rbmo.2012.03.019. View

Gilleron J, Nebout M, Scarabelli L, Senegas-Balas F, Palmero S, Segretain D . A potential novel mechanism involving connexin 43 gap junction for control of sertoli cell proliferation by thyroid hormones. J Cell Physiol. 2006; 209(1):153-61. DOI: 10.1002/jcp.20716. View

Pointis G, Gilleron J, Carette D, Segretain D . Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis. Philos Trans R Soc Lond B Biol Sci. 2010; 365(1546):1607-20. PMC: 2871914. DOI: 10.1098/rstb.2009.0114. View

Lenhart J, Ryan P, Ohleth K, Bagnell C . Expression of connexin-26, -32, and -43 gap junction proteins in the porcine cervix and uterus during pregnancy and relaxin-induced growth. Biol Reprod. 1999; 61(6):1452-9. DOI: 10.1095/biolreprod61.6.1452. View

10.

Goodenough D, Simon A, Paul D . Gap junctional intercellular communication in the mouse ovarian follicle. Novartis Found Symp. 1999; 219:226-35; discussion 235-40. DOI: 10.1002/9780470515587.ch14. View

11.

Fiorini C, Mograbi B, Cronier L, Bourget I, Decrouy X, Nebout M . Dominant negative effect of connexin33 on gap junctional communication is mediated by connexin43 sequestration. J Cell Sci. 2004; 117(Pt 20):4665-72. DOI: 10.1242/jcs.01335. View

12.

Molyneaux K, Wang Y, Schaible K, Wylie C . Transcriptional profiling identifies genes differentially expressed during and after migration in murine primordial germ cells. Gene Expr Patterns. 2004; 4(2):167-81. DOI: 10.1016/j.modgep.2003.09.002. View

13.

Hellmann P, Winterhager E, Spray D . Properties of connexin40 gap junction channels endogenously expressed and exogenously overexpressed in human choriocarcinoma cell lines. Pflugers Arch. 1996; 432(3):501-9. DOI: 10.1007/s004240050162. View

14.

Mitchell P, Burghardt R . The ontogeny of nexuses (gap junctions) in the ovary of the fetal mouse. Anat Rec. 1986; 214(3):283-8. DOI: 10.1002/ar.1092140307. View

15.

Kahiri C, Khalil M, Tekpetey F, Kidder G . Leydig cell function in mice lacking connexin43. Reproduction. 2006; 132(4):607-16. DOI: 10.1530/rep.1.01234. View

16.

Xie N, Liu L, Li Y, Yu C, Lam S, Shynlova O . Expression and function of myometrial PSF suggest a role in progesterone withdrawal and the initiation of labor. Mol Endocrinol. 2012; 26(8):1370-9. PMC: 5416987. DOI: 10.1210/me.2012-1088. View

17.

Dufresne J, Finnson K, Gregory M, Cyr D . Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication. Am J Physiol Cell Physiol. 2002; 284(1):C33-43. DOI: 10.1152/ajpcell.00111.2002. View

18.

Leung G, Cheung K, Leung C, Tsang M, Wong P . Regulation of epididymal principal cell functions by basal cells: role of transient receptor potential (Trp) proteins and cyclooxygenase-1 (COX-1). Mol Cell Endocrinol. 2004; 216(1-2):5-13. DOI: 10.1016/j.mce.2003.10.077. View

19.

Juneja S . mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse. Indian J Physiol Pharmacol. 2004; 47(2):147-56. View

20.

Tong D, Lu X, Wang H, Plante I, Lui E, Laird D . A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse. Biol Reprod. 2009; 80(6):1099-106. PMC: 2849809. DOI: 10.1095/biolreprod.108.071969. View