Recent Advances in Renal Transplantation: Antibody-mediated Rejection Takes Center Stage

Overview

Journal F1000Prime Rep

Specialty Biomedical Engineering

Date 2015 Jun 23

PMID 26097724

Citations 16

Authors

Eric Pouliquen

Alice Koenig

Chien Chia Chen

Antoine Sicard

Maud Rabeyrin

Emmanuel Morelon

Valerie Dubois

Olivier Thaunat

Affiliations

Soon will be listed here.

Abstract

Overlooked for decades, antibodies have taken center stage in renal transplantation and are now widely recognized as the first cause of allograft failure. Diagnosis of antibody-mediated rejection has considerably improved with identification of antibody-mediated lesions in graft biopsies and advances made in the detection of circulating donor-specific antibodies. Unfortunately, this progress has not yet translated into better outcomes for patients. Indeed, in the absence of a drug able to suppress antibody generation by plasma cells, available therapies can only slow down graft destruction. This review provides an overview of the current knowledge of antibody-mediated rejection and discusses future interesting research directions.

Citing Articles

γδ T Cells' Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models.

Charmetant X, Rigault G, Chen C, Kaminski H, Visentin J, Taton B Transpl Int. 2025; 38:12859.

PMID: 39944220 PMC: 11815947. DOI: 10.3389/ti.2025.12859.

Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients.

Charmetant X, Espi M, Benotmane I, Barateau V, Heibel F, Buron F Sci Transl Med. 2022; 14(636):eabl6141.

PMID: 35103481 PMC: 8939774. DOI: 10.1126/scitranslmed.abl6141.

Transcriptional Changes in Kidney Allografts with Histology of Antibody-Mediated Rejection without Anti-HLA Donor-Specific Antibodies.

Callemeyn J, Lerut E, de Loor H, Arijs I, Thaunat O, Koenig A J Am Soc Nephrol. 2020; 31(9):2168-2183.

PMID: 32641395 PMC: 7461663. DOI: 10.1681/ASN.2020030306.

Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.

Koenig A, Chen C, Marcais A, Barba T, Mathias V, Sicard A Nat Commun. 2019; 10(1):5350.

PMID: 31767837 PMC: 6877588. DOI: 10.1038/s41467-019-13113-5.

B cells in transplant tolerance and rejection: friends or foes?.

Schmitz R, Fitch Z, Schroder P, Choi A, Jackson A, Knechtle S Transpl Int. 2019; 33(1):30-40.

PMID: 31705678 PMC: 7184555. DOI: 10.1111/tri.13549.

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