Human Resistin and the RELM of Inflammation in Diabesity

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2015 Jun 23

PMID 26097512

Citations 16

Authors

Fatima Al Hannan

Kevin Gerard Culligan

Affiliations

Soon will be listed here.

Abstract

The initial discovery of resistin and resistin-like molecules (RELMs) in rodents suggested a role for these adipocytokines in molecular linkage of obesity, Type 2 Diabetes mellitus and metabolic syndrome. Since then, it became apparent that the story of resistin and RELMs was very much of mice and men. The putative role of this adipokine family evolved from that of a conveyor of insulin resistance in rodents to instigator of inflammatory processes in humans. Structural dissimilarity, variance in distribution profiles and a lack of corroborating evidence for functional similarities separate the biological functions of resistin in humans from that of rodents. Although present in gross visceral fat deposits in humans, resistin is a component of inflammation, being released from infiltrating white blood cells of the sub-clinical chronic low grade inflammatory response accompanying obesity, rather than from the adipocyte itself. This led researchers to further explore the functions of the resistin family of proteins in inflammatory-related conditions such as atherosclerosis, as well as in cancers such as endometrial and gastric cancers. Although elevated levels of resistin have been found in these conditions, whether it is causative or as a result of these conditions still remains to be determined.

Citing Articles

Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases.

Hemat Jouy S, Mohan S, Scichilone G, Mostafa A, Mahmoud A Biomedicines. 2024; 12(9).

PMID: 39335642 PMC: 11428859. DOI: 10.3390/biomedicines12092129.

Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis.

Behnoush A, Parmis Maroufi S, Reshadmanesh T, Kia Y, Norouzi M, Mohammadi S BMC Gastroenterol. 2024; 24(1):107.

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The Role of Adipokines in the Control of Pituitary Functions.

Kaminska B, Kurowicka B, Kiezun M, Dobrzyn K, Kisielewska K, Gudelska M Animals (Basel). 2024; 14(2).

PMID: 38275812 PMC: 10812442. DOI: 10.3390/ani14020353.

Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications.

Caturano A, DAngelo M, Mormone A, Russo V, Mollica M, Salvatore T Curr Issues Mol Biol. 2023; 45(8):6651-6666.

PMID: 37623239 PMC: 10453126. DOI: 10.3390/cimb45080420.

Serum resistin and the risk for hepatocellular carcinoma in diabetic patients.

Abdalla M World J Gastroenterol. 2023; 29(27):4271-4288.

PMID: 37545641 PMC: 10401662. DOI: 10.3748/wjg.v29.i27.4271.

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