SANCDB: a South African Natural Compound Database

Overview

Journal J Cheminform

Publisher Biomed Central

Specialty Chemistry

Date 2015 Jun 23

PMID 26097510

Citations 33

Authors

Rowan Hatherley

David K Brown

Thommas M Musyoka

David L Penkler

Ngonidzashe Faya

Kevin A Lobb

Ozlem Tastan Bishop

Affiliations

Soon will be listed here.

Abstract

Background: Natural products (NPs) are important to the drug discovery process. NP research efforts are expanding world-wide and South Africa is no exception to this. While freely-accessible small molecule databases, containing compounds isolated from indigenous sources, have been established in a number of other countries, there is currently no such online database in South Africa.

Description: The current research presents a South African natural compound database, named SANCDB. This is a curated and fully-referenced database containing compound information for 600 natural products extracted directly from journal articles, book chapters and theses. There is a web interface to the database, which is simple and easy to use, while allowing for compounds to be searched by a number of different criteria. Being fully referenced, each compound page contains links to the original referenced work from which the information was obtained. Further, the website provides a submission pipeline, allowing researchers to deposit compounds from their own research into the database.

Conclusions: SANCDB is currently the only web-based NP database in Africa. It aims to provide a useful resource for the in silico screening of South African NPs for drug discovery purposes. The database is supported by a submission pipeline to allow growth by entries from researchers. As such, we currently present SANCDB the starting point of a platform for a community-driven, curated database to further natural products research in South Africa. SANCDB is freely available at https://sancdb.rubi.ru.ac.za/.

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