Trophic Factors from Tissue Stem Cells for Renal Regeneration

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2015 Jun 20

PMID 26089918

Citations 14

Authors

Kenji Tsuji

Shinji Kitamura

Affiliations

Soon will be listed here.

Abstract

Stem cell therapies against renal injury have been advancing. The many trials for renal regeneration are reported to be effective in many kinds of renal injury models. Regarding the therapeutic mechanism, it is believed that stem cells contribute to make regeneration via not only direct stem cell differentiation in the injured space but also indirect effect via secreted factors from stem cells. Direct differentiation from stem cells to renal composed cells has been reported. They differentiate to renal composed cells and make functions. However, regarding renal regeneration, stem cells are discussed to secrete many kinds of growth factors, cytokines, and chemokines in paracrine or autocrine manner, which protect against renal injury, too. In addition, it is reported that stem cells have the ability to communicate with nearby cells via microvesicle-related RNA and proteins. Taken together from many reports, many secreted factors from stem cells were needed for renal regeneration orchestrally with harmony. In this review, we focused on the effects and insights of stem cells and regenerative factors from stem cells.

Citing Articles

Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors.

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Hydrogel-Mediated Local Delivery of Induced Nephron Progenitor Cell-Sourced Molecules as a Cell-Free Approach for Acute Kidney Injury.

Park K, Gao W, Zheng J, Oh K, Kim I, You S Int J Mol Sci. 2024; 25(19).

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MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury.

Tsuji K, Nakanoh H, Fukushima K, Kitamura S, Wada J Diagnostics (Basel). 2023; 13(18).

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Potential Strategies for Kidney Regeneration With Stem Cells: An Overview.

Tsuji K, Kitamura S, Wada J Front Cell Dev Biol. 2022; 10:892356.

PMID: 35586342 PMC: 9108336. DOI: 10.3389/fcell.2022.892356.

Retina stem cells, hopes and obstacles.

German O, Vallese-Maurizi H, Soto T, Rotstein N, Politi L World J Stem Cells. 2021; 13(10):1446-1479.

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