Vascular Effects of Dietary Advanced Glycation End Products

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2015 Jun 20

PMID 26089897

Citations 7

Authors

Alin Stirban

Diethelm Tschope

Affiliations

Soon will be listed here.

Abstract

Evidence has accumulated lately demonstrating that advanced glycation end products (AGEs) play an important role in the development of diabetic and cardiovascular complications as well as the development of other chronic diseases. AGEs originating from diet have a significant contribution to the AGEs body pool and therefore dietary interventions aiming at reducing AGEs load are believed to exert health promoting effects. This review summarizes the evidence from clinical studies regarding effects of dietary AGEs on the vascular system, highlighting also the different aspects of vascular tests. It also advocates an extension of dietary recommendations towards the promotion of cooking methods that reduce dietary AGEs in consumed foods.

Citing Articles

Persistent Effect of Advanced Glycated Albumin Driving Inflammation and Disturbances in Cholesterol Efflux in Macrophages.

Minanni C, Machado-Lima A, Iborra R, Okuda L, de Souza Pinto R, Santana M Nutrients. 2021; 13(10).

PMID: 34684632 PMC: 8537611. DOI: 10.3390/nu13103633.

Diet-Derived Advanced Glycation End Products (dAGEs) Induce Proinflammatory Cytokine Expression in Cardiac and Renal Tissues of Experimental Mice: Protective Effect of Curcumin.

Sowndhar Rajan B, Krishnan K, Vellaichamy E Cardiovasc Toxicol. 2021; 22(1):35-51.

PMID: 34655413 DOI: 10.1007/s12012-021-09697-4.

Advanced glycation end products induce neural tube defects through elevating oxidative stress in mice.

Li R, Zhao W, Gao B Neural Regen Res. 2018; 13(8):1368-1374.

PMID: 30106048 PMC: 6108193. DOI: 10.4103/1673-5374.235249.

Advanced glycation end products and risk of hypertension in Iranian adults: Tehran lipid and glucose study.

Mirmiran P, Yousefi R, Mottaghi A, Azizi F J Res Med Sci. 2018; 23:43.

PMID: 29937905 PMC: 5996569. DOI: 10.4103/jrms.JRMS_982_17.

The effects of whole body vibration on pulse wave velocity in men with chronic spinal cord injury.

Totosy de Zepetnek J, Miyatani M, Szeto M, Giangregorio L, Craven B J Spinal Cord Med. 2017; 40(6):795-802.

PMID: 28868990 PMC: 5778943. DOI: 10.1080/10790268.2017.1369248.

References

Meigs J, Hu F, Rifai N, Manson J . Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA. 2004; 291(16):1978-86. DOI: 10.1001/jama.291.16.1978. View

Hofmann S, Li Z, Cai W, Altomonte J, Thung S, Zeng F . Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes. 2002; 51(7):2082-9. DOI: 10.2337/diabetes.51.7.2082. View

Ahmed N . Advanced glycation endproducts--role in pathology of diabetic complications. Diabetes Res Clin Pract. 2004; 67(1):3-21. DOI: 10.1016/j.diabres.2004.09.004. View

Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V . Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A. 2002; 99(24):15596-601. PMC: 137762. DOI: 10.1073/pnas.242407999. View

Mendez J, Xie J, Aguilar-Hernandez M, Mendez-Valenzuela V . Trends in advanced glycation end products research in diabetes mellitus and its complications. Mol Cell Biochem. 2010; 341(1-2):33-41. DOI: 10.1007/s11010-010-0434-5. View

Bucala R, Mitchell R, Arnold K, Innerarity T, Vlassara H, Cerami A . Identification of the major site of apolipoprotein B modification by advanced glycosylation end products blocking uptake by the low density lipoprotein receptor. J Biol Chem. 1995; 270(18):10828-32. DOI: 10.1074/jbc.270.18.10828. View

Yan S, Ramasamy R, Schmidt A . The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease. Expert Rev Mol Med. 2009; 11:e9. PMC: 2670065. DOI: 10.1017/S146239940900101X. View

Celermajer D, Sorensen K, Gooch V, Spiegelhalter D, Miller O, Sullivan I . Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340(8828):1111-5. DOI: 10.1016/0140-6736(92)93147-f. View

Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D . Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis. 1997; 129(1):111-8. DOI: 10.1016/s0021-9150(96)06018-2. View

10.

Birlouez-Aragon I, Saavedra G, Tessier F, Galinier A, Ait-Ameur L, Lacoste F . A diet based on high-heat-treated foods promotes risk factors for diabetes mellitus and cardiovascular diseases. Am J Clin Nutr. 2010; 91(5):1220-6. DOI: 10.3945/ajcn.2009.28737. View

11.

Vlassara H, Fuh H, Makita Z, Krungkrai S, Cerami A, Bucala R . Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications. Proc Natl Acad Sci U S A. 1992; 89(24):12043-7. PMC: 50694. DOI: 10.1073/pnas.89.24.12043. View

12.

Cerami C, Founds H, Nicholl I, Mitsuhashi T, Giordano D, VanPatten S . Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A. 1998; 94(25):13915-20. PMC: 28407. DOI: 10.1073/pnas.94.25.13915. View

13.

Lin R, Reis E, Dore A, Lu M, Ghodsi N, Fallon J . Lowering of dietary advanced glycation endproducts (AGE) reduces neointimal formation after arterial injury in genetically hypercholesterolemic mice. Atherosclerosis. 2002; 163(2):303-11. DOI: 10.1016/s0021-9150(02)00008-4. View

14.

Hobbs F . Type-2 diabetes mellitus related cardiovascular risk: new options for interventions to reduce risk and treatment goals. Atheroscler Suppl. 2006; 7(4):29-32. DOI: 10.1016/j.atherosclerosissup.2006.05.005. View

15.

Vlassara H, Palace M . Glycoxidation: the menace of diabetes and aging. Mt Sinai J Med. 2003; 70(4):232-41. View

16.

Vlassara H . Advanced glycation end-products and atherosclerosis. Ann Med. 1996; 28(5):419-26. DOI: 10.3109/07853899608999102. View

17.

Negrean M, Stirban A, Stratmann B, Gawlowski T, Horstmann T, Gotting C . Effects of low- and high-advanced glycation endproduct meals on macro- and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus. Am J Clin Nutr. 2007; 85(5):1236-43. DOI: 10.1093/ajcn/85.5.1236. View

18.

Poulsen M, Bak M, Andersen J, Monosik R, Giraudi-Futin A, Holst J . Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals. Eur J Nutr. 2013; 53(2):661-72. DOI: 10.1007/s00394-013-0574-y. View

19.

Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He C . Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients. J Am Soc Nephrol. 2003; 14(3):728-31. DOI: 10.1097/01.asn.0000051593.41395.b9. View

20.

Chilelli N, Burlina S, Lapolla A . AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: a "glycoxidation-centric" point of view. Nutr Metab Cardiovasc Dis. 2013; 23(10):913-9. DOI: 10.1016/j.numecd.2013.04.004. View