Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2015 Jun 18

PMID 26082511

Citations 45

Authors

Jeffrey M Collins

Kara Loren Raphael

Charles Terry

Emily J Cartwright

Anjana Pillai

Frank A Anania

Monica M Farley

Affiliations

Soon will be listed here.

Abstract

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.

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