NTCP Opens the Door for Hepatitis B Virus Infection

Overview

Journal Antiviral Res

Publisher Elsevier

Date 2015 Jun 14

PMID 26071008

Citations 24

Authors

Huan Yan

Yang Liu

Jianhua Sui

Wenhui Li

Affiliations

Soon will be listed here.

Abstract

A liver bile acids transporter, sodium taurocholate cotransporting polypeptide (NTCP, encoded by SLC10A1) was recently identified as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). NTCP-complemented human hepatoma HepG2 cells (HepG2-NTCP) were shown to support infection of HBV and HDV in vitro, providing a much-needed and convenient cell culture system for the viruses. Identification of NTCP as a functional receptor for HBV has significantly advanced our understanding of the viral life cycle and opened new opportunities for developing anti-HBV interventions. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B".

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