Phospholipids and Fatty Acids in Breast Cancer Tissue

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 1989 Jan 1

PMID 2606932

Citations 13

Authors

K Punnonen

E Hietanen

O Auvinen

R Punnonen

Affiliations

Soon will be listed here.

Abstract

The fatty acid composition of fractionated phospholipids and neutral lipids was analyzed in human breast cancer tissues and the surrounding, apparently healthy tissue. In the cancer tissues the relative amounts of unsaturated fatty acids were increased in all the phospholipid subclasses analyzed. The differences were more marked in phosphatidylethanolamine than in the other phospholipid fractions and, furthermore, the relative amount of phosphatidyl-ethanolamine was increased in cancerous tissue. In blood-erythrocyte phospholipids, no differences in fatty acid composition could be found between breast cancer and control patients. The present study suggests that the lipid composition of cancerous breast tissues differs from that of the surrounding tissue and may be involved in carcinogenesis.

Citing Articles

Characterisation of Canine and Feline Breast Tumours, Their Metastases, and Corresponding Primary Cell Lines Using LA-REIMS and DESI-MS Imaging.

Molnar A, Horkovics-Kovats G, Kucsma N, Szego Z, Tauber B, Egri A Int J Mol Sci. 2024; 25(14).

PMID: 39062995 PMC: 11277125. DOI: 10.3390/ijms25147752.

Intraoperative Evaluation of Breast Tissues During Breast Cancer Operations Using the MasSpec Pen.

Garza K, King M, Nagi C, DeHoog R, Zhang J, Sans M JAMA Netw Open. 2024; 7(3):e242684.

PMID: 38517441 PMC: 10960202. DOI: 10.1001/jamanetworkopen.2024.2684.

Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma.

Dorado E, Doria M, Nagelkerke A, McKenzie J, Maneta-Stavrakaki S, Whittaker T J Extracell Vesicles. 2024; 13(3):e12419.

PMID: 38443328 PMC: 10914699. DOI: 10.1002/jev2.12419.

Bilayer Forming Phospholipids as Targets for Cancer Therapy.

Stoica C, Ferreira A, Hannan K, Bakovic M Int J Mol Sci. 2022; 23(9).

PMID: 35563655 PMC: 9100777. DOI: 10.3390/ijms23095266.

Non-Invasive Biomarkers for Early Detection of Breast Cancer.

Li J, Guan X, Fan Z, Ching L, Li Y, Wang X Cancers (Basel). 2020; 12(10).

PMID: 32992445 PMC: 7601650. DOI: 10.3390/cancers12102767.

References

Rosen M, Nystrom L, Wall S . Diet and cancer mortality in the counties of Sweden. Am J Epidemiol. 1988; 127(1):42-9. DOI: 10.1093/oxfordjournals.aje.a114789. View

Abraham S, HILLYARD L . Effect of dietary 18-carbon fatty acids on growth of transplantable mammary adenocarcinomas in mice. J Natl Cancer Inst. 1983; 71(3):601-5. View

Tinsley I, Schmitz J, Pierce D . Influence of dietary fatty acids on the incidence of mammary tumors in the C3H mouse. Cancer Res. 1981; 41(4):1460-5. View

Willett W, Stampfer M, Colditz G, Rosner B, Hennekens C, Speizer F . Dietary fat and the risk of breast cancer. N Engl J Med. 1987; 316(1):22-8. DOI: 10.1056/NEJM198701013160105. View

Caleffi M, Ashraf J, Rowe P, Thomas B, Fentiman I . A comparison of the fatty acid profiles of subcutaneous fat from women with breast cancer, benign breast disease and normal controls. Anticancer Res. 1987; 7(6):1305-7. View

Minoura T, Takata T, Sakaguchi M, Takada H, Yamamura M, Hioki K . Effect of dietary eicosapentaenoic acid on azoxymethane-induced colon carcinogenesis in rats. Cancer Res. 1988; 48(17):4790-4. View

BARTLETT G . Phosphorus assay in column chromatography. J Biol Chem. 1959; 234(3):466-8. View

Neoptolemos J, Clayton H, Heagerty A, NICHOLSON M, Johnson B, Mason J . Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer. Br J Cancer. 1988; 58(5):575-9. PMC: 2246818. DOI: 10.1038/bjc.1988.262. View

Correa P . Epidemiological correlations between diet and cancer frequency. Cancer Res. 1981; 41(9 Pt 2):3685-90. View

10.

Abraham S, Faulkin L, HILLYARD L, Mitchell D . Effect of dietary fat on tumorigenesis in the mouse mammary gland. J Natl Cancer Inst. 1984; 72(6):1421-9. View

11.

Gabor H, HILLYARD L, Abraham S . Effect of dietary fat on growth kinetics of transplantable mammary adenocarcinoma in BALB/c mice. J Natl Cancer Inst. 1985; 74(6):1299-305. View

12.

Wynder E . The dietary environment and cancer. J Am Diet Assoc. 1977; 71(4):385-92. View

13.

Thomas B, ODea J, Fentiman I . Erythrocyte membrane stearic and oleic acid ratios in breast cancer. Br J Surg. 1988; 75(11):1078-9. DOI: 10.1002/bjs.1800751109. View

14.

Agren J, Hanninen O, Laitinen M, Seppanen K, Bernhardt I, Fogelholm L . Boreal freshwater fish diet modifies the plasma lipids and prostanoids and membrane fatty acids in man. Lipids. 1988; 23(10):924-9. DOI: 10.1007/BF02536338. View

15.

Punnonen K, Puustinen T, Jansen C . Incorporation and distribution of dihomo-gamma-linolenic acid, arachidonic acid, and eicosapentaenoic acid in cultured human keratinocytes. Prostaglandins. 1986; 31(2):263-70. DOI: 10.1016/0090-6980(86)90052-3. View

16.

HOPKINS G, Kennedy T, Carroll K . Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague-Dawley rats by 7,12-dimethylbenz[a]anthracene. J Natl Cancer Inst. 1981; 66(3):517-22. View

17.

Kidwell W, Monaco M, Wicha M, Smith G . Unsaturated fatty acid requirements for growth and survival of a rat mammary tumor cell line. Cancer Res. 1978; 38(11 Pt 2):4091-100. View

18.

Hietanen E, Punnonen K, Punnonen R, Auvinen O . Fatty acid composition of phospholipids and neutral lipids and lipid peroxidation in human breast cancer and lipoma tissue. Carcinogenesis. 1986; 7(12):1965-9. DOI: 10.1093/carcin/7.12.1965. View

19.

WELSCH C, Aylsworth C . Enhancement of murine mammary tumorigenesis by feeding high levels of dietary fat: a hormonal mechanism?. J Natl Cancer Inst. 1983; 70(2):215-21. View

20.

Lane H, Butel J, Howard C, Shepherd F, Halligan R, Medina D . The role of high levels of dietary fat in 7,12-dimethylbenzanthracene-induced mouse mammary tumorigenesis: lack of an effect on lipid peroxidation. Carcinogenesis. 1985; 6(3):403-7. DOI: 10.1093/carcin/6.3.403. View