Association Study of Dopamine Transporter Gene (DAT1) Variable Tandem Repeat Sequence (VNTR) with Obsessive-compulsive Disorder in Chinese Han Population

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2015 Jun 12

PMID 26064393

Citations 3

Authors

Shaoyan Zhang

Weihua Jiang

Xiuming Tang

Quanchen Xu

Jingli Wang

Rui Gui

Xinhua Zhang

Shiguo Liu

Affiliations

Soon will be listed here.

Abstract

Objective: Multiple evidence suggests an involvement of the dopamine neurotransmitter system in Obsessive-compulsive disorder (OCD). Therefore, we explore the association of 3'UTR region of 40 bp variable tandem repeat (VNTR) polymorphism in Dopamine Transporter Gene (DAT1) in Chinese Han population.

Methods: A total of 305 OCD patients and 435 healthy individuals were recruited for the study. OCD was diagnosed with the Forth Edition (DSM-IV) diagnostic criteria. After polymerase chain reaction of VNTR was used to evaluate the 40 bp VNTR polymorphism in DAT1, a case-control association analysis was performed by the χ(2) test.

Results: The results showed that no association was found between OCD patients and controls for the genotype distribution (X(2) =0.743, P=0.690, df=2) as well as allelic (X(2)=0.172, P=0.678, OR=0.928, 95% Cl=0.885-1.224) distribution.

Conclusions: Our data suggest that the 40 bp VNTR polymorphism in DAT1 may not be associated with susceptibility to OCD in the Chinese Han population studied. However, this result needed to be replicated from different populations.

Citing Articles

Association analyses reveal gender-specific associations of DAT1 40-bp VNTR and -839C/T polymorphisms with obsessive-compulsive disorder and obsessive-compulsive symptoms.

Cotrin J, Fontenelle L, Kohlrausch F Mol Biol Rep. 2019; 46(5):5155-5162.

PMID: 31325142 DOI: 10.1007/s11033-019-04971-9.

Genetics of obsessive-compulsive disorder.

Purty A, Nestadt G, Samuels J, Viswanath B Indian J Psychiatry. 2019; 61(Suppl 1):S37-S42.

PMID: 30745675 PMC: 6343406. DOI: 10.4103/psychiatry.IndianJPsychiatry_518_18.

DNA Methylation at the DAT Promoter and Risk for Psychopathology: Intergenerational Transmission between School-Age Youths and Their Parents in a Community Sample.

Cimino S, Cerniglia L, Ballarotto G, Marzilli E, Pascale E, DAddario C Front Psychiatry. 2018; 8:303.

PMID: 29375406 PMC: 5767582. DOI: 10.3389/fpsyt.2017.00303.

References

Nestadt G, Grados M, Samuels J . Genetics of obsessive-compulsive disorder. Psychiatr Clin North Am. 2010; 33(1):141-58. PMC: 2824902. DOI: 10.1016/j.psc.2009.11.001. View

Tibrewal P, Kiran Kumar H, Shubha G, Subhashree D, Purushottam M, Thennarasu K . Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population. Indian J Med Res. 2011; 132:690-5. PMC: 3102456. View

Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S . The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J. 2002; 1(2):152-6. DOI: 10.1038/sj.tpj.6500026. View

Hemmings S, Kinnear C, Niehaus D, Moolman-Smook J, Lochner C, Knowles J . Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2003; 13(2):93-8. DOI: 10.1016/s0924-977x(02)00129-3. View

Cavallini M, Albertazzi M, Bianchi L, Bellodi L . Anticipation of age at onset of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder. Psychiatry Res. 2002; 111(1):1-9. DOI: 10.1016/s0165-1781(02)00140-3. View

Nordstrom E, Burton F . A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry. Mol Psychiatry. 2002; 7(6):617-25, 524. DOI: 10.1038/sj.mp.4001144. View

Fontenelle L, Mendlowicz M, Versiani M . The descriptive epidemiology of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2006; 30(3):327-37. DOI: 10.1016/j.pnpbp.2005.11.001. View

Mill J, Asherson P, Browes C, DSouza U, Craig I . Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet. 2002; 114(8):975-9. DOI: 10.1002/ajmg.b.10948. View

Miguita K, Cordeiro Q, Siqueira-Roberto J, Shavitt R, Castillo J, Castillo A . Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample. Arq Neuropsiquiatr. 2007; 65(4A):936-41. DOI: 10.1590/s0004-282x2007000600002. View

10.

Yoon D, Rippel C, Kobets A, Morris C, Lee J, Williams P . Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3). Am J Med Genet B Neuropsychiatr Genet. 2006; 144B(5):605-10. DOI: 10.1002/ajmg.b.30466. View

11.

Hawi Z, Lowe N, Kirley A, Gruenhage F, Nothen M, Greenwood T . Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci. Mol Psychiatry. 2003; 8(3):299-308. DOI: 10.1038/sj.mp.4001290. View

12.

Vandenbergh D, Persico A, Hawkins A, Griffin C, Li X, Jabs E . Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 1992; 14(4):1104-6. DOI: 10.1016/s0888-7543(05)80138-7. View

13.

Vermeire S, Audenaert K, De Meester R, Vandermeulen E, Waelbers T, De Spiegeleer B . Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiatry Res. 2012; 201(1):78-87. DOI: 10.1016/j.pscychresns.2011.06.006. View

14.

Arnold P, Rosenberg D, Mundo E, Tharmalingam S, Kennedy J, Richter M . Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl). 2004; 174(4):530-8. DOI: 10.1007/s00213-004-1847-1. View

15.

Chabane N, Millet B, Delorme R, Lichtermann D, Mathieu F, Laplanche J . Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans. Neurosci Lett. 2004; 363(2):154-6. DOI: 10.1016/j.neulet.2004.03.065. View

16.

Chen C, Chen S, Mill J, Huang Y, Lin S, Curran S . The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. Mol Psychiatry. 2003; 8(4):393-6. DOI: 10.1038/sj.mp.4001238. View

17.

Walitza S, Scherag A, Renner T, Hinney A, Remschmidt H, Herpertz-Dahlmann B . Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. J Neural Transm (Vienna). 2008; 115(7):1071-8. DOI: 10.1007/s00702-008-0051-6. View

18.

Lind P, Eriksson C, Wilhelmsen K . Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population. Psychiatr Genet. 2009; 19(3):117-25. DOI: 10.1097/YPG.0b013e32832a4f7b. View

19.

Szekely A, Ronai Z, Nemoda Z, Kolmann G, Gervai J, Sasvari-Szekely M . Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms. Am J Med Genet B Neuropsychiatr Genet. 2004; 126B(1):106-10. DOI: 10.1002/ajmg.b.20134. View

20.

Roman T, Schmitz M, Polanczyk G, EIZIRIK M, Rohde L, Hutz M . Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet. 2001; 105(5):471-8. DOI: 10.1002/ajmg.1408. View