Predictors of Quality of Life Among Individuals with Schizophrenia

Overview

Journal Neuropsychiatr Dis Treat

Publisher Dove Medical Press

Specialty Psychiatry

Date 2015 Jun 12

PMID 26064055

Citations 8

Authors

Sirijit Suttajit

Sutrak Pilakanta

Affiliations

Soon will be listed here.

Abstract

Purpose: The study reported here aimed to evaluate both biological and psychosocial factors as predictors for quality of life as well as to examine the associations between the factors and quality of life in individuals with schizophrenia.

Methods: Eighty individuals with schizophrenia were recruited to the study. The Thai version of the World Health Organization Quality of Life-BREF was utilized to measure the quality of life. The five Marder subscales of the Positive and Negative Syndrome Scale were applied. Other tools for measurement included the Calgary Depression Scale for Schizophrenia and six social support deficits (SSDs). Pearson/Spearman correlation coefficients and the independent t-test were used for the statistical analysis to determine the associations of variables and the overall quality of life and the four domain scores. A multiple linear regression analysis of the overall quality of life and four domain scores was applied to determine their predictors.

Results: The Positive and Negative Syndrome Scale total score, positive symptoms, negative symptoms, disorganized thought, and anxiety/depression showed a significant correlation with the overall quality of life and most of the four domain scores. Depression, SSDs, and adverse drug events showed a significant correlation with a poorer overall quality of life. The multiple linear regression model revealed that negative symptoms, depression, and seeing a relative less often than once per week were predictors for the overall quality of life (adjusted R (2)=0.472). Negative symptoms were also found to be the main factors predicting a decrease in the four domains of quality of life - physical health, psychological, social relationships, and environment.

Conclusion: Negative symptoms, depression, and poor contact with relatives were the foremost predictors of poor quality of life in individuals with schizophrenia. Positive symptoms, negative symptoms, disorganized thought, anxiety/depression, SSDs, and adverse events were also found to be correlated with quality of life.

Citing Articles

Negative Symptoms of Schizophrenia: New Prospects of Cariprazine Treatment.

Reznik A, Arbuzov A, Murin S Consort Psychiatr. 2024; 1(2):43-51.

PMID: 39006904 PMC: 11240126. DOI: 10.17650/2712-7672-2020-1-2-43-51.

Duration of the untreated period affects bone mineral density in psychiatric patients requiring long-term hospitalization: A cross-sectional study.

Kaga I, Iwata H, Tokushige A, Akata T, Ueda S PCN Rep. 2024; 1(3):e25.

PMID: 38868695 PMC: 11114306. DOI: 10.1002/pcn5.25.

Defar S, Abraham Y, Reta Y, Deribe B, Jisso M, Yeheyis T Front Public Health. 2023; 11:1134032.

PMID: 36875411 PMC: 9978447. DOI: 10.3389/fpubh.2023.1134032.

Mediators of quality of life change in people with severe psychotic disorders treated in integrated care: ACCESS II study.

Schroter R, Lambert M, Rohenkohl A, Kraft V, Ruhl F, Luedecke D Eur Psychiatry. 2022; 66(1):e1.

PMID: 36329654 PMC: 9879911. DOI: 10.1192/j.eurpsy.2022.2332.

Prediction of quality of life in schizophrenia using machine learning models on data from Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial.

Beaudoin M, Hudon A, Giguere C, Potvin S, Dumais A Schizophrenia (Heidelb). 2022; 8(1):29.

PMID: 35314708 PMC: 8938459. DOI: 10.1038/s41537-022-00236-w.

References

Xiang Y, Weng Y, Leung C, Tang W, Ungvari G . Quality of life of Chinese schizophrenia outpatients in Hong Kong: relationship to sociodemographic factors and symptomatology. Aust N Z J Psychiatry. 2007; 41(5):442-9. DOI: 10.1080/00048670701261228. View

Eack S, Newhill C . Psychiatric symptoms and quality of life in schizophrenia: a meta-analysis. Schizophr Bull. 2007; 33(5):1225-37. PMC: 2632363. DOI: 10.1093/schbul/sbl071. View

Vancampfort D, Probst M, Scheewe T, Maurissen K, Sweers K, Knapen J . Lack of physical activity during leisure time contributes to an impaired health related quality of life in patients with schizophrenia. Schizophr Res. 2011; 129(2-3):122-7. DOI: 10.1016/j.schres.2011.03.018. View

NORMAN R, Malla A, McLean T, Voruganti L, Cortese L, McIntosh E . The relationship of symptoms and level of functioning in schizophrenia to general wellbeing and the Quality of Life Scale. Acta Psychiatr Scand. 2000; 102(4):303-9. DOI: 10.1034/j.1600-0447.2000.102004303.x. View

Suttajit S, Srisurapanont M, Pilakanta S, Charnsil C, Suttajit S . Reliability and validity of the Thai version of the Calgary Depression Scale for Schizophrenia. Neuropsychiatr Dis Treat. 2013; 9:113-8. PMC: 3552548. DOI: 10.2147/NDT.S40292. View

Suttajit S, Pilakanta S . Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia. Neuropsychiatr Dis Treat. 2013; 9:941-6. PMC: 3709830. DOI: 10.2147/NDT.S47450. View

. Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychol Med. 1998; 28(3):551-8. DOI: 10.1017/s0033291798006667. View

Fitzgerald P, Williams C, Corteling N, Filia S, Brewer K, Adams A . Subject and observer-rated quality of life in schizophrenia. Acta Psychiatr Scand. 2001; 103(5):387-92. DOI: 10.1034/j.1600-0447.2001.00254.x. View

Saxena S, Orley J . Quality of life assessment: The world health organization perspective. Eur Psychiatry. 2009; 12 Suppl 3:263s-6s. DOI: 10.1016/S0924-9338(97)89095-5. View

10.

Meyer J, Nasrallah H, McEvoy J, Goff D, Davis S, Chakos M . The Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE) Schizophrenia Trial: clinical comparison of subgroups with and without the metabolic syndrome. Schizophr Res. 2005; 80(1):9-18. DOI: 10.1016/j.schres.2005.07.015. View

11.

Ruggeri M, Bisoffi G, Fontecedro L, Warner R . Subjective and objective dimensions of quality of life in psychiatric patients: a factor analytical approach: The South Verona Outcome Project 4. Br J Psychiatry. 2001; 178:268-75. DOI: 10.1192/bjp.178.3.268. View

12.

Hardy S, Concato J, Gill T . Resilience of community-dwelling older persons. J Am Geriatr Soc. 2004; 52(2):257-62. DOI: 10.1111/j.1532-5415.2004.52065.x. View

13.

Huppert J, Weiss K, Lim R, Pratt S, Smith T . Quality of life in schizophrenia: contributions of anxiety and depression. Schizophr Res. 2001; 51(2-3):171-80. DOI: 10.1016/s0920-9964(99)00151-6. View

14.

COHEN C, Talavera N, Hartung R . Predictors of subjective well-being among older, community-dwelling persons with schizophrenia. Am J Geriatr Psychiatry. 1997; 5(2):145-55. View

15.

Suttajit S, Srisurapanont M, Xia J, Suttajit S, Maneeton B, Maneeton N . Quetiapine versus typical antipsychotic medications for schizophrenia. Cochrane Database Syst Rev. 2013; (5):CD007815. DOI: 10.1002/14651858.CD007815.pub2. View

16.

Foldemo A, Wardig R, Bachrach-Lindstrom M, Edman G, Holmberg T, Lindstrom T . Health-related quality of life and metabolic risk in patients with psychosis. Schizophr Res. 2013; 152(1):295-9. DOI: 10.1016/j.schres.2013.11.029. View

17.

Morgado A, Smith M, Lecrubier Y, Widlocher D . Depressed subjects unwittingly overreport poor social adjustment which they reappraise when recovered. J Nerv Ment Dis. 1991; 179(10):614-9. DOI: 10.1097/00005053-199110000-00005. View

18.

Fervaha G, Agid O, Takeuchi H, Foussias G, Remington G . Life satisfaction among individuals with schizophrenia in the Clinical Antipsychotic Trial of Intervention Effectiveness (CATIE) study. Am J Psychiatry. 2013; 170(9):1061-2. DOI: 10.1176/appi.ajp.2013.13010060. View

19.

von Hausswolff-Juhlin Y, Bjartveit M, Lindstrom E, Jones P . Schizophrenia and physical health problems. Acta Psychiatr Scand Suppl. 2009; (438):15-21. DOI: 10.1111/j.1600-0447.2008.01309.x. View

20.

Velligan D, Miller A, Olsen J . Predicting quality of life from symptomatology in schizophrenia at exacerbation and stabilization. Psychiatry Res. 1999; 86(2):131-42. DOI: 10.1016/s0165-1781(99)00023-2. View