Mediatory Effect of Circulating Vaspin on Resting Metabolic Rate in Obese Individuals

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2015 Jun 11

PMID 26058881

Citations 13

Authors

Sajjad Moradi

Khadijeh Mirzaei

Ahmed Abdulahi Abdurahman

Seyed Ali Keshavarz

Arash Hossein-Nezhad

Affiliations

Soon will be listed here.

Abstract

Background/objective: Vaspin is a recently identified adipokine related to obesity and insulin sensitivity. The precise mechanism of vaspin in the body is not well known, and its function in resting metabolic rate (RMR) is even less understood. Therefore, the main aim of this study was to investigate the effect of circulating vaspin on RMR in obese people.

Materials And Methods: A total of 222 obese participants were included in the current comparative cross-sectional study. Body composition was measured using body composition analyzer. RMR was measured by means of indirect calorimetry. For the measurement of vaspin serum concentrations, an enzyme-linked immunosorbent assay was used. Dietary intake was assessed using 3-day 24-h dietary recall.

Results: Between low and high circulating vaspin groups, there was significant difference for sex (P = 0.03), fat percent (P = 0.008), RMR per weight (P < 0.001), and RMR per fat free mass (FFM) (P = 0.007). However, there was no statistical difference between the groups in dietary intake after adjustment for energy intake (P > 0.05). Furthermore, individuals with higher level of RMR had higher vaspin concentration. Weight, visceral fat, FFM, and fat mass had significant effect on increasing RMR (P < 0.05) but after adding vaspin as a covariate in the general linear model; visceral fat (P = 0.078) and fat mass (P = 0.339) missed their effectiveness.

Conclusion: Circulating vaspin level is higher in women than in men in obese individuals. Moreover, it was found that vaspin had mediator effect between visceral fat and fat mass associations with RMR in obese participants.

Citing Articles

Shin J, Kang I, Lee M Nutrients. 2025; 16(24.

PMID: 39771044 PMC: 11676649. DOI: 10.3390/nu16244423.

Association of Serum Vaspin Concentration with Metabolic Disorders in Obese Individuals.

Pilarski L, Pelczynska M, Koperska A, Seraszek-Jaros A, Szulinska M, Bogdanski P Biomolecules. 2023; 13(3).

PMID: 36979443 PMC: 10046748. DOI: 10.3390/biom13030508.

Vitamin D insufficiency and its association with adipokines and atherogenic indices in patients with metabolic syndrome: A case-control study.

Amirkhizi F, Khademi Z, Hamedi Shahraki S, Rahimlou M Front Endocrinol (Lausanne). 2023; 14:1080138.

PMID: 36742396 PMC: 9895380. DOI: 10.3389/fendo.2023.1080138.

The relationship between dietary phytochemical index and resting metabolic rate mediated by inflammatory factors in overweight and obese women: a cross-sectional study.

Mirzababaei A, Taheri A, Rasaei N, Mehranfar S, Jamili S, Clark C BMC Womens Health. 2022; 22(1):313.

PMID: 35879706 PMC: 9317090. DOI: 10.1186/s12905-022-01894-9.

The Association Between Low Carbohydrate Diet and Resting Metabolic Rate in Overweight and Obese Women: A Cross-Sectional Study.

Sajjadi S, Mirzababaei A, Pooyan S, Rasaei N, Yekaninejad M, Shiraseb F Clin Nutr Res. 2022; 11(1):50-61.

PMID: 35223681 PMC: 8844535. DOI: 10.7762/cnr.2022.11.1.50.

References

Kennedy A, Gettys T, Watson P, Wallace P, Ganaway E, Pan Q . The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab. 1997; 82(4):1293-300. DOI: 10.1210/jcem.82.4.3859. View

Ozgen M, Koca S, Dagli N, Balin M, Ustundag B, Isik A . Serum adiponectin and vaspin levels in rheumatoid arthritis. Arch Med Res. 2010; 41(6):457-63. DOI: 10.1016/j.arcmed.2010.08.012. View

Choi S, Kwak S, Lee Y, Moon M, Lim S, Park Y . Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women. Clin Endocrinol (Oxf). 2011; 75(5):628-35. DOI: 10.1111/j.1365-2265.2011.04095.x. View

Pannacciulli N, Bunt J, Ortega E, Funahashi T, Salbe A, Bogardus C . Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates. J Clin Endocrinol Metab. 2006; 91(4):1600-3. PMC: 1578760. DOI: 10.1210/jc.2005-2271. View

Aktas B, Yilmaz Y, Eren F, Yonal O, Kurt R, Ozen Alahdab Y . Serum levels of vaspin, obestatin, and apelin-36 in patients with nonalcoholic fatty liver disease. Metabolism. 2010; 60(4):544-9. DOI: 10.1016/j.metabol.2010.05.008. View

Gulcelik N, Karakaya J, Gedik A, Usman A, Gurlek A . Serum vaspin levels in type 2 diabetic women in relation to microvascular complications. Eur J Endocrinol. 2008; 160(1):65-70. DOI: 10.1530/EJE-08-0723. View

Kloting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Schon M . Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun. 2005; 339(1):430-6. DOI: 10.1016/j.bbrc.2005.11.039. View

Auguet T, Quintero Y, Riesco D, Morancho B, Terra X, Crescenti A . New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Med Genet. 2011; 12:60. PMC: 3107780. DOI: 10.1186/1471-2350-12-60. View

Kang E, Magkos F, Sienkiewicz E, Mantzoros C . Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans. Eur J Endocrinol. 2011; 164(6):911-7. PMC: 3104072. DOI: 10.1530/EJE-11-0052. View

10.

Loos R, Ruchat S, Rankinen T, Tremblay A, Perusse L, Bouchard C . Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study. Am J Clin Nutr. 2007; 85(1):26-34. DOI: 10.1093/ajcn/85.1.26. View

11.

von Loeffelholz C, Mohlig M, Arafat A, Isken F, Spranger J, Mai K . Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans. Eur J Endocrinol. 2009; 162(3):507-13. DOI: 10.1530/EJE-09-0737. View

12.

Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, Curat C . Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J. 2004; 18(14):1657-69. DOI: 10.1096/fj.04-2204com. View

13.

Kirchgessner T, Uysal K, Wiesbrock S, Marino M, Hotamisligil G . Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest. 1998; 100(11):2777-82. PMC: 508482. DOI: 10.1172/JCI119824. View

14.

Trayhurn P . Adipocyte biology. Obes Rev. 2007; 8 Suppl 1:41-4. DOI: 10.1111/j.1467-789X.2007.00316.x. View

15.

Seeger J, Ziegelmeier M, Bachmann A, Lossner U, Kratzsch J, Bluher M . Serum levels of the adipokine vaspin in relation to metabolic and renal parameters. J Clin Endocrinol Metab. 2007; 93(1):247-51. DOI: 10.1210/jc.2007-1853. View

16.

Coppack S . Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc. 2001; 60(3):349-56. DOI: 10.1079/pns2001110. View

17.

Fu B, Yamawaki H, Okada M, Hara Y . Vaspin can not inhibit TNF-alpha-induced inflammation of human umbilical vein endothelial cells. J Vet Med Sci. 2009; 71(9):1201-7. DOI: 10.1292/jvms.71.1201. View

18.

Rosenbaum M, Murphy E, Heymsfield S, Matthews D, Leibel R . Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab. 2002; 87(5):2391-4. DOI: 10.1210/jcem.87.5.8628. View

19.

Velojic Golubovic M, Dimic D, Antic S, Radenkovic S, Djindjic B, Jovanovic M . Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women--the effect of body weight reduction by caloric restriction. Vojnosanit Pregl. 2013; 70(3):284-91. DOI: 10.2298/vsp1303284v. View

20.

Shoelson S, Herrero L, Naaz A . Obesity, inflammation, and insulin resistance. Gastroenterology. 2007; 132(6):2169-80. DOI: 10.1053/j.gastro.2007.03.059. View