The Relationship Between the Clinical Course and Cytokine in a Patient with Cigarette Smoking-induced Acute Eosinophilic Pneumonia - A Case Report

Overview

Journal Respir Med Case Rep

Date 2015 Jun 10

PMID 26056772

Citations 2

Authors

Yuta Kono

Kenji Tsushima

Koichi Yamaguchi

Seiko Soeda

Akahito Fujiwara

Shinya Sugiyama

Yuki Togashi

Satoshi Kasagi

Yasuhiro Setoguchi

Affiliations

Soon will be listed here.

Abstract

A 19-year-old female was admitted to our hospital because of a sudden onset fever and cough, and she was diagnosed to have acute eosinophilic pneumonia (AEP). The cause was thought to be cigarette smoking, because she had started smoking just before the development of AEP and her condition improved after cigarette smoking cessation, without corticosteroid treatment. The cytokines which are thought to be involved in eosinophilic accumulation in the lungs were analyzed using bronchoalveolar lavage fluid (BALF) and serum. Of the analyzed cytokines, only regulated on activation, normal T cell expressed and secreted (RANTES) increased in the serum after the improvement. RANTES is a unique chemokine which attracts not only eosinophils, but also T cells. Interestingly, in this case, the eosinophil count in the blood increased in parallel with the lymphocyte count after the improvement. These findings are interesting because it may help to understand the pathogenesis of AEP and the role of RANTES.

Citing Articles

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A combination of predispositions and exposures as responsible for acute eosinophilic pneumonia.

Amiconi S, Hirl B Multidiscip Respir Med. 2014; 9(1):7.

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