Modifying Role of GSTP1 Polymorphism on the Association Between Tea Fluoride Exposure and the Brick-Tea Type Fluorosis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Jun 6

PMID 26046522

Citations 11

Authors

Junhua Wu

Wei Wang

Yang Liu

Jing Sun

Yan Ye

Bingyun Li

Xiaona Liu

Hongxu Liu

Zhenqi Sun

Mang Li

Jing Cui

Dianjun Sun

Yanmei Yang

Yanhui Gao

Affiliations

Soon will be listed here.

Abstract

Background: Brick tea type fluorosis is a public health concern in the north-west area of China. The association between SNPs of genes influencing bone mass and fluorosis has attracted attention, but the association of SNPs with the risk of brick-tea type of fluorosis has not been reported.

Objective: To investigate the modifying roles of GSTP1 rs1695 polymorphisms on this association.

Methods: A cross-sectional study was conducted. Brick-tea water was tested by the standard of GB1996-2005 (China). Urinary fluoride was tested by the standard of WS/T 89-2006 (China). Skeletal fluorosis was diagnosed by X-ray, the part we scheduled was forearm, shank, and pelvic, then diagnosed the skeletal fluorosis by the standard of WS/192-2008 (China). Gene polymorphism was tested by Sequenom MassARRAY system.

Result: The prevalence rate in different ethnical participants was different: Tibetan individuals had the highest prevalence rate of skeletal fluorosis. There were significant differences in genotype frequencies of GSTP1 Rs1695 among different ethnical participants (p<0.001): Tibetan, Mongolian and Han subjects with homozygous wild type (GSTP1-AA) genotype were numerically higher than Kazakh and Russian subjects (p<0.001). Compared to Tibetan participants who carried homozygous A allele of GSTP1 Rs1695, Tibetan participants who carried G allele had a significantly decreased risk of skeletal fluorosis (OR = 0.558 [95% CI, 0.326-0.955]). For Kazakh participants, a decreased risk of skeletal fluorosis among carriers of the G allele was limited to non high-loaded fluoride status (OR = 0. 166 [95% CI, 0.035-0.780] vs. OR = 1.478 [95% CI, 0.866-2.552] in participants with high-loaded fluoride status). Neither SNP-IF nor SNP-age for GSTP1 Rs1695 was observed.

Conclusion: The prevalence rate of the brick tea type fluorosis might have ethnic difference. For Tibetan individuals, who had the highest prevalence rate, G allele of GSTP1 Rs1695 might be a protective factor for brick tea type skeletal fluorosis.

Citing Articles

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References

Cao J, Zhao Y, Liu J . Brick tea consumption as the cause of dental fluorosis among children from Mongol, Kazak and Yugu populations in China. Food Chem Toxicol. 1997; 35(8):827-33. DOI: 10.1016/s0278-6915(97)00049-5. View

Sogaard C, Richards A, Mosekilde L . Marked decrease in trabecular bone quality after five years of sodium fluoride therapy--assessed by biomechanical testing of iliac crest bone biopsies in osteoporotic patients. Bone. 1994; 15(4):393-9. DOI: 10.1016/8756-3282(94)90815-x. View

Wang Q, Cui K, Xu Y, Gao Y, Zhao J, Li D . Coal-burning endemic fluorosis is associated with reduced activity in antioxidative enzymes and Cu/Zn-SOD gene expression. Environ Geochem Health. 2013; 36(1):107-15. DOI: 10.1007/s10653-013-9522-2. View

Gupta P, Sandesh N . Estimation of fluoride concentration in tea infusions, prepared from different forms of tea, commercially available in Mathura city. J Int Soc Prev Community Dent. 2014; 2(2):64-8. PMC: 3894083. DOI: 10.4103/2231-0762.109371. View

Chandrajith R, Abeypala U, Dissanayake C, Tobschall H . Fluoride in Ceylon tea and its implications to dental health. Environ Geochem Health. 2007; 29(5):429-34. DOI: 10.1007/s10653-007-9087-z. View

Huang Q, Ng M, Cheung C, Chan V, Sham P, Kung A . Identification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in Chinese. Hum Hered. 2006; 61(4):237-43. DOI: 10.1159/000095216. View

Yang G, Shu X, Ruan Z, Cai Q, Jin F, Gao Y . Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma. Cancer. 2004; 103(1):52-8. DOI: 10.1002/cncr.20729. View

Ba Y, Zhang H, Wang G, Wen S, Yang Y, Zhu J . Association of dental fluorosis with polymorphisms of estrogen receptor gene in Chinese children. Biol Trace Elem Res. 2010; 143(1):87-96. DOI: 10.1007/s12011-010-8848-1. View

Mandinic Z, Curcic M, Antonijevic B, Lekic C, Carevic M . Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis. Food Chem Toxicol. 2009; 47(6):1080-4. DOI: 10.1016/j.fct.2009.01.038. View

10.

Wen S, Li A, Cui L, Huang Q, Chen H, Guo X . The relationship of PTH Bst BI polymorphism, calciotropic hormone levels, and dental fluorosis of children in China. Biol Trace Elem Res. 2012; 147(1-3):84-90. DOI: 10.1007/s12011-011-9313-5. View

11.

Peacock M, Koller D, Fishburn T, Krishnan S, Lai D, Hui S . Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men. J Clin Endocrinol Metab. 2005; 90(5):3060-6. DOI: 10.1210/jc.2004-2143. View

12.

Ba Y, Huang H, Yang Y, Cui L, Zhu J, Zhu C . The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People's Republic of China. Ecotoxicol Environ Saf. 2009; 72(8):2158-61. DOI: 10.1016/j.ecoenv.2009.08.014. View

13.

Emekli-Alturfan E, Yarat A, Akyuz S . Fluoride levels in various black tea, herbal and fruit infusions consumed in Turkey. Food Chem Toxicol. 2009; 47(7):1495-8. DOI: 10.1016/j.fct.2009.03.036. View

14.

Yoder K, Mabelya L, Robison V, Dunipace A, Brizendine E, Stookey G . Severe dental fluorosis in a Tanzanian population consuming water with negligible fluoride concentration. Community Dent Oral Epidemiol. 1998; 26(6):382-93. DOI: 10.1111/j.1600-0528.1998.tb01976.x. View

15.

Everett E, McHenry M, Reynolds N, Eggertsson H, Sullivan J, Kantmann C . Dental fluorosis: variability among different inbred mouse strains. J Dent Res. 2002; 81(11):794-8. DOI: 10.1177/0810794. View

16.

Lung S, Cheng H, Fu C . Potential exposure and risk of fluoride intakes from tea drinks produced in Taiwan. J Expo Sci Environ Epidemiol. 2007; 18(2):158-66. DOI: 10.1038/sj.jes.7500574. View

17.

Krishnamachari K . Skeletal fluorosis in humans: a review of recent progress in the understanding of the disease. Prog Food Nutr Sci. 1986; 10(3-4):279-314. View

18.

Kumar J, Swango P, Lininger L, Leske G, Green E, Haley V . Changes in dental fluorosis and dental caries in Newburgh and Kingston, New York. Am J Public Health. 1998; 88(12):1866-70. PMC: 1509052. DOI: 10.2105/ajph.88.12.1866. View

19.

Jha S, Mishra V, Sharma D, Damodaran T . Fluoride in the environment and its metabolism in humans. Rev Environ Contam Toxicol. 2011; 211:121-42. DOI: 10.1007/978-1-4419-8011-3_4. View

20.

Gong Y, Vikkula M, Boon L, Liu J, Beighton P, Ramesar R . Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet. 1996; 59(1):146-51. PMC: 1915094. View