Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2015 Jun 6

PMID 26045577

Citations 8

Authors

C A Raji

H Eyre

S H Wei

D E Bredesen

S Moylan

M Law

G Small

P M Thompson

R M Friedlander

D H Silverman

B T Baune

T A Hoang

N Salamon

A W Toga

M W Vernooij

Affiliations

Soon will be listed here.

Abstract

Preventive neuroradiology is a new concept supported by growing literature. The main rationale of preventive neuroradiology is the application of multimodal brain imaging toward early and subclinical detection of brain disease and subsequent preventive actions through identification of modifiable risk factors. An insightful example of this is in the area of age-related cognitive decline, mild cognitive impairment, and dementia with potentially modifiable risk factors such as obesity, diet, sleep, hypertension, diabetes, depression, supplementation, smoking, and physical activity. In studying this link between lifestyle and cognitive decline, brain imaging markers may be instrumental as quantitative measures or even indicators of early disease. The purpose of this article is to provide an overview of the major studies reflecting how lifestyle factors affect the brain and cognition aging. In this hot topics review, we will specifically focus on obesity and physical activity.

Citing Articles

Zhang W, Zhou Y, Zhang Y, Zhan X PLoS One. 2024; 19(8):e0304646.

PMID: 39146339 PMC: 11326595. DOI: 10.1371/journal.pone.0304646.

The Brain Economy: Advancing Brain Science to Better Understand the Modern Economy.

Eyre H, Hynes W, Ayadi R, Swieboda P, Berk M, Ibanez A Malays J Med Sci. 2024; 31(1):1-13.

PMID: 38456111 PMC: 10917588. DOI: 10.21315/mjms2024.31.1.1.

Multimodal imaging of the aging brain: Baseline findings of the LoCARPoN study.

Nair P, Prasad K, Balasundaram P, Vibha D, Dwivedi S, Gaikwad S Aging Brain. 2023; 3:100075.

PMID: 37180873 PMC: 10173278. DOI: 10.1016/j.nbas.2023.100075.

Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis.

Wang Z, Sun Z, Zhang M, Xiong K, Zhou F Front Neurol. 2022; 13:997181.

PMID: 36419534 PMC: 9677942. DOI: 10.3389/fneur.2022.997181.

Cerebral Pathology and Cognition in Diabetes: The Merits of Multiparametric Neuroimaging.

van Bussel F, Backes W, Hofman P, van Oostenbrugge R, van Boxtel M, Verhey F Front Neurosci. 2017; 11:188.

PMID: 28424581 PMC: 5380729. DOI: 10.3389/fnins.2017.00188.

References

Morra J, Tu Z, Apostolova L, Green A, Avedissian C, Madsen S . Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Neuroimage. 2008; 45(1 Suppl):S3-15. PMC: 2733354. DOI: 10.1016/j.neuroimage.2008.10.043. View

Liang K, Mintun M, Fagan A, Goate A, Bugg J, Holtzman D . Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Ann Neurol. 2010; 68(3):311-8. PMC: 2936720. DOI: 10.1002/ana.22096. View

Boyle C, Raji C, Erickson K, Lopez O, Becker J, Gach H . Physical activity, body mass index, and brain atrophy in Alzheimer's disease. Neurobiol Aging. 2014; 36 Suppl 1:S194-S202. PMC: 4303036. DOI: 10.1016/j.neurobiolaging.2014.05.036. View

Raji C, Ho A, Parikshak N, Becker J, Lopez O, Kuller L . Brain structure and obesity. Hum Brain Mapp. 2009; 31(3):353-64. PMC: 2826530. DOI: 10.1002/hbm.20870. View

Braskie M, Small G, Bookheimer S . Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging. 2008; 31(9):1532-42. PMC: 2965069. DOI: 10.1016/j.neurobiolaging.2008.08.016. View

Poirier P, Despres J, Bertrand O . Identifying which patients with diabetes should be tested for the presence of coronary artery disease--the importance of baseline electrocardiogram and exercise testing. Can J Cardiol. 2006; 22 Suppl A:9A-15A. DOI: 10.1016/s0828-282x(06)70973-4. View

Selkoe D . Preventing Alzheimer's disease. Science. 2012; 337(6101):1488-92. DOI: 10.1126/science.1228541. View

DeCarli C, Mungas D, Harvey D, Reed B, Weiner M, Chui H . Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia. Neurology. 2004; 63(2):220-7. PMC: 1820872. DOI: 10.1212/01.wnl.0000130531.90205.ef. View

Wells R, Kerr C, Wolkin J, Dossett M, Davis R, Walsh J . Meditation for adults with mild cognitive impairment: a pilot randomized trial. J Am Geriatr Soc. 2013; 61(4):642-5. PMC: 3666869. DOI: 10.1111/jgs.12179. View

10.

Niemann C, Godde B, Voelcker-Rehage C . Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults. Front Aging Neurosci. 2014; 6:170. PMC: 4131191. DOI: 10.3389/fnagi.2014.00170. View

11.

Nagamatsu L, Handy T, Hsu C, Voss M, Liu-Ambrose T . Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment. Arch Intern Med. 2012; 172(8):666-8. PMC: 3514552. DOI: 10.1001/archinternmed.2012.379. View

12.

Di Marco L, Marzo A, Munoz-Ruiz M, Ikram M, Kivipelto M, Ruefenacht D . Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies. J Alzheimers Dis. 2014; 42(1):119-35. DOI: 10.3233/JAD-132225. View

13.

Head D, Bugg J, Goate A, Fagan A, Mintun M, Benzinger T . Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. Arch Neurol. 2012; 69(5):636-43. PMC: 3583203. DOI: 10.1001/archneurol.2011.845. View

14.

Gates N, Fiatarone Singh M, Sachdev P, Valenzuela M . The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials. Am J Geriatr Psychiatry. 2013; 21(11):1086-97. DOI: 10.1016/j.jagp.2013.02.018. View

15.

Eyre H, Baune B . Assessing for unique immunomodulatory and neuroplastic profiles of physical activity subtypes: a focus on psychiatric disorders. Brain Behav Immun. 2013; 39:42-55. DOI: 10.1016/j.bbi.2013.10.026. View

16.

Okonkwo O, Schultz S, Oh J, Larson J, Edwards D, Cook D . Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology. 2014; 83(19):1753-60. PMC: 4239838. DOI: 10.1212/WNL.0000000000000964. View

17.

Kirk-Sanchez N, McGough E . Physical exercise and cognitive performance in the elderly: current perspectives. Clin Interv Aging. 2014; 9:51-62. PMC: 3872007. DOI: 10.2147/CIA.S39506. View

18.

Bugg J, Head D . Exercise moderates age-related atrophy of the medial temporal lobe. Neurobiol Aging. 2009; 32(3):506-14. PMC: 2891908. DOI: 10.1016/j.neurobiolaging.2009.03.008. View

19.

Tian Q, Erickson K, Simonsick E, Aizenstein H, Glynn N, Boudreau R . Physical activity predicts microstructural integrity in memory-related networks in very old adults. J Gerontol A Biol Sci Med Sci. 2014; 69(10):1284-90. PMC: 4172036. DOI: 10.1093/gerona/glt287. View

20.

Barnes D, Whitmer R, Yaffe K . Physical activity and dementia: The need for prevention trials. Exerc Sport Sci Rev. 2007; 35(1):24-9. DOI: 10.1097/JES.0b013e31802d6bc2. View