Modulation of the Intracortical LFP During Action Execution and Observation

Overview

Journal J Neurosci

Specialty Neurology

Date 2015 Jun 5

PMID 26041914

Citations 13

Authors

Stephan Waldert

Ganesh Vigneswaran

Roland Philipp

Roger N Lemon

Alexander Kraskov

Affiliations

Soon will be listed here.

Abstract

The activity of mirror neurons in macaque ventral premotor cortex (PMv) and primary motor cortex (M1) is modulated by the observation of another's movements. This modulation could underpin well documented changes in EEG/MEG activity indicating the existence of a mirror neuron system in humans. Because the local field potential (LFP) represents an important link between macaque single neuron and human noninvasive studies, we focused on mirror properties of intracortical LFPs recorded in the PMv and M1 hand regions in two macaques while they reached, grasped and held different objects, or observed the same actions performed by an experimenter. Upper limb EMGs were recorded to control for covert muscle activity during observation.The movement-related potential (MRP), investigated as intracortical low-frequency LFP activity (<9 Hz), was modulated in both M1 and PMv, not only during action execution but also during action observation. Moreover, the temporal LFP modulations during execution and observation were highly correlated in both cortical areas. Beta power in both PMv and M1 was clearly modulated in both conditions. Although the MRP was detected only during dynamic periods of the task (reach/grasp/release), beta decreased during dynamic and increased during static periods (hold).Comparison of LFPs for different grasps provided evidence for partially nonoverlapping networks being active during execution and observation, which might be related to different inputs to motor areas during these conditions. We found substantial information about grasp in the MRP corroborating its suitability for brain-machine interfaces, although information about grasp was generally low during action observation.

Citing Articles

Variations in Clustering of Multielectrode Local Field Potentials in the Motor Cortex of Macaque Monkeys during a Reach-and-Grasp Task.

Chambellant F, Falaki A, Moreau-Debord I, French R, Serrano E, Quessy S eNeuro. 2024; 11(9).

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Differential Modulation of Local Field Potentials in the Primary and Premotor Cortices during Ipsilateral and Contralateral Reach to Grasp in Macaque Monkeys.

Falaki A, Quessy S, Dancause N J Neurosci. 2024; 44(21).

PMID: 38589229 PMC: 11112639. DOI: 10.1523/JNEUROSCI.1161-23.2024.

Grasp-specific high-frequency broadband mirror neuron activity during reach-and-grasp movements in humans.

Dreyer A, Michalke L, Perry A, Chang E, Lin J, Knight R Cereb Cortex. 2022; 33(10):6291-6298.

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Cognitive genomics of learning delay and low level of social performance monitoring in macaque.

Ninomiya T, Noritake A, Tatsumoto S, Go Y, Isoda M Sci Rep. 2022; 12(1):16539.

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A causal role for frontal cortico-cortical coordination in social action monitoring.

Ninomiya T, Noritake A, Kobayashi K, Isoda M Nat Commun. 2020; 11(1):5233.

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