Hepatitis C Virus and Autophagy

Overview

Journal Biol Chem

Specialty Biochemistry

Date 2015 May 30

PMID 26024249

Citations 39

Authors

Linya Wang

Jing-Hsiung James Ou

Affiliations

Soon will be listed here.

Abstract

Autophagy is a catabolic process by which cells remove protein aggregates and damaged organelles for recycling. It can also be used by cells to remove intracellular microbial pathogens, including viruses, in a process known as xenophagy. However, many viruses have developed mechanisms to subvert this intracellular antiviral response and even use this pathway to support their own replications. Hepatitis C virus (HCV) is one such virus and is an important human pathogen that can cause severe liver diseases. Recent studies indicated that HCV could activate the autophagic pathway to support its replication. This review summarizes the current knowledge on the interplay between HCV and autophagy and how this interplay affects HCV replication and host innate immune responses.

Citing Articles

The Interplay Between Viral Infection and Cell Death: A Ping-Pong Effect.

Nourazarian A, Yousefi H, Biray Avci C, Shademan B, Behboudi E Adv Virol. 2025; 2025:5750575.

PMID: 39959654 PMC: 11824611. DOI: 10.1155/av/5750575.

The interplay between probiotics and host autophagy: mechanisms of action and emerging insights.

Sadeghloo Z, Nabavi-Rad A, Zali M, Klionsky D, Yadegar A Autophagy. 2024; 21(2):260-282.

PMID: 39291740 PMC: 11759520. DOI: 10.1080/15548627.2024.2403277.

An Update on the Study of the Molecular Mechanisms Involved in Autophagy during Bacterial Pathogenesis.

Rahman M, Sarker A, Ayaz M, Shatabdy A, Haque N, Jalouli M Biomedicines. 2024; 12(8).

PMID: 39200221 PMC: 11351677. DOI: 10.3390/biomedicines12081757.

HCV-induced autophagy and innate immunity.

Lee J, Ou J Front Immunol. 2024; 15:1305157.

PMID: 38370419 PMC: 10874285. DOI: 10.3389/fimmu.2024.1305157.

Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.

Bender D, Koulouri A, Wen X, Glitscher M, Schollmeier A, Fernandes da Costa L PLoS Pathog. 2024; 20(2):e1011976.

PMID: 38315728 PMC: 10868826. DOI: 10.1371/journal.ppat.1011976.

References

Ait-Goughoulte M, Kanda T, Meyer K, Ryerse J, Ray R, Ray R . Hepatitis C virus genotype 1a growth and induction of autophagy. J Virol. 2007; 82(5):2241-9. PMC: 2258951. DOI: 10.1128/JVI.02093-07. View

Liang C, Lee J, Inn K, Gack M, Li Q, Roberts E . Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 2008; 10(7):776-87. PMC: 2878716. DOI: 10.1038/ncb1740. View

Sir D, Chen W, Choi J, Wakita T, Yen T, Ou J . Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology. 2008; 48(4):1054-61. PMC: 2562598. DOI: 10.1002/hep.22464. View

Joyce M, Walters K, Lamb S, Yeh M, Zhu L, Kneteman N . HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS Pathog. 2009; 5(2):e1000291. PMC: 2647842. DOI: 10.1371/journal.ppat.1000291. View

Li S, Ye L, Yu X, Xu B, Li K, Zhu X . Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation. Virology. 2009; 391(2):257-64. DOI: 10.1016/j.virol.2009.06.039. View

Dreux M, Gastaminza P, Wieland S, Chisari F . The autophagy machinery is required to initiate hepatitis C virus replication. Proc Natl Acad Sci U S A. 2009; 106(33):14046-51. PMC: 2729017. DOI: 10.1073/pnas.0907344106. View

Simonsen A, Tooze S . Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol. 2009; 186(6):773-82. PMC: 2753151. DOI: 10.1083/jcb.200907014. View

Tanida I, Fukasawa M, Ueno T, Kominami E, Wakita T, Hanada K . Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy. 2009; 5(7):937-45. DOI: 10.4161/auto.5.7.9243. View

Mizui T, Yamashina S, Tanida I, Takei Y, Ueno T, Sakamoto N . Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy. J Gastroenterol. 2009; 45(2):195-203. PMC: 7088329. DOI: 10.1007/s00535-009-0132-9. View

10.

Guevin C, Manna D, Belanger C, Konan K, Mak P, Labonte P . Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection. Virology. 2010; 405(1):1-7. PMC: 2925245. DOI: 10.1016/j.virol.2010.05.032. View

11.

Ferraris P, Blanchard E, Roingeard P . Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes. J Gen Virol. 2010; 91(Pt 9):2230-7. DOI: 10.1099/vir.0.022186-0. View

12.

Sun Q, Westphal W, Wong K, Tan I, Zhong Q . Rubicon controls endosome maturation as a Rab7 effector. Proc Natl Acad Sci U S A. 2010; 107(45):19338-43. PMC: 2984168. DOI: 10.1073/pnas.1010554107. View

13.

Youle R, Narendra D . Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2010; 12(1):9-14. PMC: 4780047. DOI: 10.1038/nrm3028. View

14.

Ke P, Chen S . Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. J Clin Invest. 2010; 121(1):37-56. PMC: 3007134. DOI: 10.1172/JCI41474. View

15.

Shrivastava S, Raychoudhuri A, Steele R, Ray R, Ray R . Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes. Hepatology. 2011; 53(2):406-14. PMC: 3335751. DOI: 10.1002/hep.24073. View

16.

Rautou P, Cazals-Hatem D, Feldmann G, Mansouri A, Grodet A, Barge S . Changes in autophagic response in patients with chronic hepatitis C virus infection. Am J Pathol. 2011; 178(6):2708-15. PMC: 3124343. DOI: 10.1016/j.ajpath.2011.02.021. View

17.

Desai M, Gong B, Chan T, Davey R, Soong L, Kolokoltsov A . Differential, type I interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver. Gastroenterology. 2011; 141(2):674-85, 685.e1-6. PMC: 3152629. DOI: 10.1053/j.gastro.2011.04.060. View

18.

Su W, Chao T, Huang Y, Weng S, Jeng K, Lai M . Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J Virol. 2011; 85(20):10561-71. PMC: 3187495. DOI: 10.1128/JVI.00173-11. View

19.

Li X, Chiu Y, Ismail A, Behrendt C, Wight-Carter M, Hooper L . Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis. Proc Natl Acad Sci U S A. 2011; 108(42):17390-5. PMC: 3198352. DOI: 10.1073/pnas.1107114108. View

20.

Taguwa S, Kambara H, Fujita N, Noda T, Yoshimori T, Koike K . Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus. J Virol. 2011; 85(24):13185-94. PMC: 3233170. DOI: 10.1128/JVI.06099-11. View