Synthesis and Activity of Platinum(II) Complexes of Two Fluorenylspirohydantoins Against a Human Tumour Cell Line

Overview

Journal Biotechnol Biotechnol Equip

Specialty Biotechnology

Date 2015 May 29

PMID 26019515

Citations 1

Authors

Petja Marinova

Marin Marinov

Maria Kazakova

Yana Feodorova

Plamen Penchev

Victoria Sarafian

Neyko Stoyanov

Affiliations

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Abstract

This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9'-fluorene)-spiro-5-hydantoin (L1) and (9'-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet-visible, attenuated total reflection Fourier transform infrared (ATR-FTIR), and H- and C-NMR for Pt(II) compounds and additionally Raman spectroscopy for free ligands. Based on the experimental data, the most probable structure of the complexes is suggested. In the present study, we have examined cytotoxic activity of (9'-fluorene)-spiro-5-hydantoin (L1) and (9'-fluorene)-spiro-5-(2-thiohydantoin) (L2) and their Pt(II) complexes on the retinoblastoma cell line WERI-Rb-1.

Citing Articles

Two-in-one strategy for fluorene-based spirocycles Pd(0)-catalyzed spiroannulation of -iodobiaryls with bromonaphthols.

Tan B, Liu L, Zheng H, Cheng T, Zhu D, Yang X Chem Sci. 2021; 11(37):10198-10203.

PMID: 34094284 PMC: 8162402. DOI: 10.1039/d0sc04386a.

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