Primary Hepatic Angiosarcoma: A Report of Two Cases and Literature Review

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2015 May 29

PMID 26019478

Citations 31

Authors

Yi-Ping Zhu

Yan-Min Chen

Erik Matro

Ren-Biao Chen

Zhi-Nong Jiang

Yi-Ping Mou

Hong-Jie Hu

Chao-Jie Huang

Guan-Yu Wang

Affiliations

Soon will be listed here.

Abstract

Primary hepatic angiosarcoma (PHA) is a rare malignancy that carries a poor prognosis. Of 1500 patients who underwent hepatectomy for primary hepatic tumors between 1994 and 2013 at our center, two patients were pathologically diagnosed with PHA. Clinical characteristics, treatment modalities, and outcomes of the two patients were collected and analyzed. Both patients underwent hepatectomy and had a postoperative survival time of 8 and 16 mo, respectively. A search of PubMed yielded eight references reporting 35 cases of PHA published between 2004 and 2013. On the basis of the presented cases and review of the literature, we endorse complete surgical resection as the mainstay definitive treatment of PHA, with adjuvant postoperative chemotherapy potentially improving survival. Palliative chemotherapy is an option in advanced hepatic angiosarcoma.

Citing Articles

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References

Bhati C, Bhatt A, Starkey G, Hubscher S, Bramhall S . Acute liver failure due to primary angiosarcoma: a case report and review of literature. World J Surg Oncol. 2008; 6:104. PMC: 2567320. DOI: 10.1186/1477-7819-6-104. View

Bioulac-Sage P, Laumonier H, Laurent C, Blanc J, Balabaud C . Benign and malignant vascular tumors of the liver in adults. Semin Liver Dis. 2008; 28(3):302-14. DOI: 10.1055/s-0028-1085098. View

Matthaei H, Krieg A, Schmelzle M, Boelke E, Poremba C, Rogiers X . Long-term survival after surgery for primary hepatic sarcoma in adults. Arch Surg. 2009; 144(4):339-44. DOI: 10.1001/archsurg.2009.30. View

Park Y, Kim J, Kim K, Lee I, Yoon H, Ko G . Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolization. Clin Radiol. 2009; 64(8):779-85. DOI: 10.1016/j.crad.2009.02.019. View

Egea Valenzuela J, Lopez Poveda M, Perez Fuenzalida F, Garre Sanchez C, Martinez Barba E, Carballo Alvarez F . Hepatic angiosarcoma. Presentation of two cases. Rev Esp Enferm Dig. 2009; 101(6):430-4, 434-7. DOI: 10.4321/s1130-01082009000600010. View

Bonaccorsi-Riani E, Lerut J . Liver transplantation and vascular tumours. Transpl Int. 2010; 23(7):686-91. DOI: 10.1111/j.1432-2277.2010.01107.x. View

Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T . FDG PET for giant cavernous hemangioma: important clue to differentiate from a malignant vascular tumor in the liver. Clin Nucl Med. 2011; 35(12):924-6. DOI: 10.1097/RLU.0b013e3181f9de11. View

Huang N, Wann S, Chang H, Lin S, Wang J, Guo H . Arsenic, vinyl chloride, viral hepatitis, and hepatic angiosarcoma: a hospital-based study and review of literature in Taiwan. BMC Gastroenterol. 2011; 11:142. PMC: 3280174. DOI: 10.1186/1471-230X-11-142. View

Yang K, Leow V, Hasnan M, Manisekar K . Primary hepatic angiosarcoma: difficulty in clinical, radiological, and pathological diagnosis. Med J Malaysia. 2012; 67(1):127-8. View

10.

Duan X, Li Q . Primary hepatic angiosarcoma: a retrospective analysis of 6 cases. J Dig Dis. 2012; 13(7):381-5. DOI: 10.1111/j.1751-2980.2012.00600.x. View

11.

Wang L, Lv K, Chang X, Xia Y, Yang Z, Jiang Y . Contrast-enhanced ultrasound study of primary hepatic angiosarcoma: a pitfall of non-enhancement. Eur J Radiol. 2011; 81(9):2054-9. DOI: 10.1016/j.ejrad.2011.06.026. View

12.

Rao P, Lahat G, Arnold C, Gavino A, Lahat S, Hornick J . Angiosarcoma: a tissue microarray study with diagnostic implications. Am J Dermatopathol. 2013; 35(4):432-7. DOI: 10.1097/DAD.0b013e318271295a. View

13.

Bruegel M, Muenzel D, Waldt S, Specht K, Rummeny E . Hepatic angiosarcoma: cross-sectional imaging findings in seven patients with emphasis on dynamic contrast-enhanced and diffusion-weighted MRI. Abdom Imaging. 2012; 38(4):745-54. DOI: 10.1007/s00261-012-9967-2. View

14.

Wang Z, Wei L . [Primary hepatic angiosarcoma: a clinical and pathological analysis]. Zhonghua Bing Li Xue Za Zhi. 2013; 42(6):376-80. DOI: 10.3760/cma.j.issn.0529-5807.2013.06.005. View

15.

Groeschl R, Miura J, Oshima K, Clark Gamblin T, Turaga K . Does histology predict outcome for malignant vascular tumors of the liver?. J Surg Oncol. 2013; 109(5):483-6. DOI: 10.1002/jso.23517. View

16.

Wang Z, Yuan J, Chen W, Wei L . Transcription factor ERG is a specific and sensitive diagnostic marker for hepatic angiosarcoma. World J Gastroenterol. 2014; 20(13):3672-9. PMC: 3974537. DOI: 10.3748/wjg.v20.i13.3672. View

17.

Singla S, Papavasiliou P, Powers B, Gaughan J, von Mehren M, Watson J . Challenges in the treatment of angiosarcoma: a single institution experience. Am J Surg. 2014; 208(2):254-9. DOI: 10.1016/j.amjsurg.2014.01.007. View

18.

Rademaker J, Widjaja A, Galanski M . Hepatic hemangiosarcoma: imaging findings and differential diagnosis. Eur Radiol. 2000; 10(1):129-33. DOI: 10.1007/s003300050018. View

19.

Peterson M, BARON R, Rankin S . Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 2000; 175(1):165-70. DOI: 10.2214/ajr.175.1.1750165. View

20.

Ohmoto K, Hirokawa M, Takesue M, Yamamoto S . Hepatic angiosarcoma with early central enhancement and arterioportal shunt on dynamic CT. Hepatogastroenterology. 2001; 47(36):1717-8. View