A Novel Role for the Condensin II Complex in Cellular Senescence

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2015 May 29

PMID 26017022

Citations 16

Authors

Yuhki Yokoyama

Hengrui Zhu

Rugang Zhang

Ken-Ichi Noma

Affiliations

Soon will be listed here.

Abstract

Although cellular senescence is accompanied by global alterations in genome architecture, how the genome is restructured during the senescent processes is not well understood. Here, we show that the hCAP-H2 subunit of the condensin II complex exists as either a full-length protein or an N-terminus truncated variant (ΔN). While the full-length hCAP-H2 associates with mitotic chromosomes, the ΔN variant exists as an insoluble nuclear structure. When overexpressed, both hCAP-H2 isoforms assemble this nuclear architecture and induce senescence-associated heterochromatic foci (SAHF). The hCAP-H2ΔN protein accumulates as cells approach senescence, and hCAP-H2 knockdown inhibits oncogene-induced senescence. This study identifies a novel mechanism whereby condensin drives senescence via nuclear/genomic reorganization.

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