Diagnosis of Lung Cancer by SHOX2 Gene Methylation Assay

Overview

Journal Mol Diagn Ther

Specialties Molecular Biology
Pathology
Pharmacology

Date 2015 May 28

PMID 26014676

Citations 16

Authors

Lele Song

Haotian Yu

Yuemin Li

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the most prevalent cancer in the world. Few effective and cheap methods are available so far for early detection and screening of lung cancer. Although histological and cytological examinations are gold standards in lung cancer diagnosis, patients are always at late stages when diagnosis is confirmed. Therefore, new diagnostic methods are needed urgently to increase the early diagnostic rate, enhance the confirmed diagnostic rate, and reduce mortality. The SHOX2 gene methylation assay has become a promising option for the above purposes. It has been shown to enhance the confirmed diagnostic rate of lung cancer in several clinical trials when combined with histological or cytological assays, and has the potential to become an early diagnostic tool. This article reviews the outcome of clinical trials using the SHOX2 gene methylation assay alone or in combination with other examinations, and suggests its future applications and research directions.

Citing Articles

Meta-analysis of the accuracy for RASSF1A methylation in bronchial aspirates for the diagnosis of lung cancer.

Chen X, He S, Chen M, Chen F, Wu P, Shi P PLoS One. 2024; 19(7):e0299447.

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Research progress and applications of epigenetic biomarkers in cancer.

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Detection of the DNA methylation of seven genes contribute to the early diagnosis of lung cancer.

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Evaluation of DNA methylation levels of and in plasma of patients with head and neck squamous cell carcinoma using droplet digital PCR.

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