Brain Metabolomics in Rats After Administration of Ketamine

Overview

Journal Biomed Chromatogr

Publisher Wiley

Specialties Biology
Chemistry

Date 2015 May 28

PMID 26014584

Citations 8

Authors

Congcong Wen

Meiling Zhang

Yuan Zhang

Fa Sun

Jianshe Ma

Lufeng Hu

Guanyang Lin

Xianqin Wang

Affiliations

Soon will be listed here.

Abstract

In this study, we developed a brain metabolomic method, based on gas chromatography-mass spectrometry (GC/MS), to evaluate the effect of ketamine on rats. Pattern recognition analysis, including both principal component analysis and partial least squares-discriminate analysis revealed that ketamine induced metabolic perturbations. Compared with the control group, the levels of glycerol, uridine, cholesterol in rat brain of the ketamine group (50 mg/kg, 14 days) decreased, while the urea levels increased. Our results indicate that metabolomic methods based on GC/MS may be useful to elucidate ketamine abuse through the exploration of biomarkers.

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