Reverse Correlation Between MicroRNA-145 and FSCN1 Affecting Gastric Cancer Migration and Invasion

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 May 27

PMID 26010149

Citations 20

Authors

Jia-Jia Chen

Wang-Yu Cai

Xue-Wen Liu

Qi-Cong Luo

Gang Chen

Wei-Feng Huang

Na Li

Jian-Chun Cai

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRs) play important roles in modulating gene expression during the processes of tumorigenesis and tumor development. Previous studies have found that miR-145 is down-regulated in the stomach neoplasm and is related to tumor migration and invasion. However, both the molecular mechanism and function of miR-145 in gastric cancer remain unclear. The present study is the first demonstration of the significant down-regulation of miR-145 expression in infiltrative gastric cancer compared to expanding gastric cancer. Additionally, correlation analyses revealed strong inverse correlations between miR-145 and FSCN1 expression levels in infiltrative gastric cancer. Furthermore, we demonstrated that miR-145 directly targets FSCN1 and suppresses cell migration and invasion in gastric cancer. Knocking down the expression of FSCN1 led to the suppression of migration and invasion in gastric cancer cells, and re-expressing FSCN1 in miR-145-overexpressing cells reversed their migration and invasion defects. Thus, we concluded that miR-145 regulates cell migration and invasion in gastric cancer primarily by directly targeting FSCN1.

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