Scanning the Human Genome and the Horizon: the Potential and Pitfalls of Pharmacogenetics and Stratified Medicine

Overview

Journal Br J Gen Pract

Specialty Public Health

Date 2015 May 27

PMID 26009508

Authors

Barbara A Jennings

Tom Shakespeare

Yoon K Loke

Affiliations

Soon will be listed here.

References

Pirmohamed M, James S, Meakin S, Green C, Scott A, Walley T . Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004; 329(7456):15-9. PMC: 443443. DOI: 10.1136/bmj.329.7456.15. View

Smart A, Martin P, Parker M . Tailored medicine: whom will it fit? The ethics of patient and disease stratification. Bioethics. 2004; 18(4):322-42. DOI: 10.1111/j.1467-8519.2004.00400.x. View

Bentley D, Balasubramanian S, Swerdlow H, Smith G, Milton J, Brown C . Accurate whole human genome sequencing using reversible terminator chemistry. Nature. 2008; 456(7218):53-9. PMC: 2581791. DOI: 10.1038/nature07517. View

Lander E . Initial impact of the sequencing of the human genome. Nature. 2011; 470(7333):187-97. DOI: 10.1038/nature09792. View

Schully S, Benedicto C, Khoury M . How can we stimulate translational research in cancer genomics beyond bench to bedside?. Genet Med. 2012; 14(1):169-70. DOI: 10.1038/gim.2011.12. View

Ciriello G, Miller M, Aksoy B, Senbabaoglu Y, Schultz N, Sander C . Emerging landscape of oncogenic signatures across human cancers. Nat Genet. 2013; 45(10):1127-33. PMC: 4320046. DOI: 10.1038/ng.2762. View

Hood L, Flores M . A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. N Biotechnol. 2012; 29(6):613-24. DOI: 10.1016/j.nbt.2012.03.004. View

Murtaza M, Dawson S, Tsui D, Gale D, Forshew T, Piskorz A . Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature. 2013; 497(7447):108-12. DOI: 10.1038/nature12065. View

Caudle K, Thorn C, Klein T, Swen J, McLeod H, Diasio R . Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013; 94(6):640-5. PMC: 3831181. DOI: 10.1038/clpt.2013.172. View

10.

Check Hayden E . Technology: The $1,000 genome. Nature. 2014; 507(7492):294-5. DOI: 10.1038/507294a. View

11.

Clyne M, Schully S, Dotson W, Douglas M, Gwinn M, Kolor K . Horizon scanning for translational genomic research beyond bench to bedside. Genet Med. 2014; 16(7):535-8. PMC: 4079725. DOI: 10.1038/gim.2013.184. View

12.

Hastings R, de Wert G, Fowler B, Krawczak M, Vermeulen E, Bakker E . The changing landscape of genetic testing and its impact on clinical and laboratory services and research in Europe. Eur J Hum Genet. 2012; 20(9):911-6. PMC: 3421130. DOI: 10.1038/ejhg.2012.56. View