The Role of Gangliosides in Neurodevelopment

Overview

Journal Nutrients

Date 2015 May 27

PMID 26007338

Citations 64

Authors

Kate Palmano

Angela Rowan

Rozey Guillermo

Jian Guan

Paul McJarrow

Affiliations

Soon will be listed here.

Abstract

Gangliosides are important components of neuronal cell membranes and it is widely accepted that they play a critical role in neuronal and brain development. They are functionally involved in neurotransmission and are thought to support the formation and stabilization of functional synapses and neural circuits required as the structural basis of memory and learning. Available evidence, as reviewed herein, suggests that dietary gangliosides may impact positively on cognitive functions, particularly in the early postnatal period when the brain is still growing. Further, new evidence suggests that the mechanism of action may be through an effect on the neuroplasticity of the brain, mediated through enhanced synaptic plasticity in the hippocampus and nigro-striatal dopaminergic pathway.

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