Metabolic Signatures of Human Breast Cancer

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2015 May 26

PMID 26005711

Citations 44

Authors

Prachi Mishra

Stefan Ambs

Affiliations

Soon will be listed here.

Abstract

Metabolomics has emerged as a new discovery tool with the promise of identifying therapeutic targets in cancer. Recent discoveries described essential metabolomic pathways in breast cancer and characterized oncometabolites that drive tumor growth and progression. Oncogenes like and tumor suppressor genes like prominently affect breast cancer biology through regulation of cell metabolism and mitochondrial biogenesis. These findings indicate that tumors with dominant mutations could be susceptible to inhibitors of disease metabolism. Moreover, various pre-clinical and clinical studies have linked tumor metabolism to therapeutic response and patient survival. Thus, recent advances suggest that metabolic profiling provides new opportunities to improve outcomes in breast cancer. In this review, we have summarized some of the identified roles of oncometabolites in breast cancer biology and highlight their clinical utility.

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