Regulating Tumor Myeloid-Derived Suppressor Cells by MicroRNAs

Overview

Journal Cancer Cell Microenviron

Date 2015 May 26

PMID 26005707

Citations 27

Authors

Siqi Chen

Yi Zhang

Timothy M Kuzel

Bin Zhang

Affiliations

Soon will be listed here.

Abstract

Myeloid-derived suppressor cells (MDSCs) are one of the major cell components responsible for cancer immune evasion. Studying mechanisms associated with the regulation of MDSCs is becoming appreciated as another way to manipulate immune responses. MicroRNAs (miRNAs) have been recognized as substances which may interact with MDSCs, and eight miRNAs including miR-17-5p, miR-20a, miR-223, miR-21, miR-155, miR-494, miR-690 and miR-101 are of particular interest regarding MDSC accumulation and function. We have reviewed the data supporting this activity of these entities.

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