System-level Impact of Mitochondria on Fungal Virulence: to Metabolism and Beyond

Overview

Journal FEMS Yeast Res

Publisher Oxford University Press

Specialty Microbiology

Date 2015 May 24

PMID 26002841

Citations 43

Authors

Richard Calderone

Dongmei Li

Ana Traven

Affiliations

Soon will be listed here.

Abstract

The mitochondrion plays wide-ranging roles in eukaryotic cell physiology. In pathogenic fungi, this central metabolic organelle mediates a range of functions related to disease, from fitness of the pathogen to developmental and morphogenetic transitions to antifungal drug susceptibility. In this review, we present the latest findings in this area. We focus on likely mechanisms of mitochondrial impact on fungal virulence pathways through metabolism and stress responses, but also potentially via control over signaling pathways. We highlight fungal mitochondrial proteins that lack human homologs, and which could be inhibited as a novel approach to antifungal drug strategy.

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